랫드에 주입된 세피오라이트에 의한 폐기능 변화 및 생체내구성 평가 = Changes of Pulmonary Function and Biopersistence Evaluation of Sepiolite in Sprague-Dawely Rats

다국어 초록 (Multilingual Abstract)

Two kinds of sepiolite (sepiolite 1, sepiolite 2), a 500℃ heat treated sepiolite (sepiolite 500), and a 700℃ heat treated sepiolite (sepiolite 700) were analyzed for their physicochemical properties. After these sepiolites were instilled into rat lungs, the effects of these substances on lung function and biochemical changes were evaluated. In addition, the fibers in the lungs were counted and characterized after the lungs were treated for electron microscopical analysis. The lungs instilled with sepiolites increased their weight and tidal volume statistically significantly compared with the unexposed control. The numbers of lymphocytes and polymorphonuclear cells (PMN) in the bronchoalveolar lavage (BAL) fluid also increased compared with the control, indicating the sepiolite induced inflammation. The heat treated sepiolites, however, did not show any toxicological differences from the untreated sepiolites. Although sepiolite showed less change in fiber atomic % compositions ( sepiolite 500, Si 0.9%, p <0.01 ; sepiolite 700, Si 3.7%, p<0.05) than chrysotile (Si 9.7%, p<0.01), the durability of the fibers in the lungs could not be determined in this subchronic experiment.

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