Immunomodulatory Effects of Hypocrellin A on MHC-restricted Antigen Processing

다국어 초록 (Multilingual Abstract)

Hypocrellin A has gained much attention in recent years due to its light-induced antitumor, antifungal and antiviral activities.
Here we report that hypocrellin A exerts immunomodulatory effects on MHC-restricted presentation of antigen.
Hypocrellin A inhibited class II-MHC restricted presentation of exogenous antigen, but not class I MHC-restricted presentation of exogenous antigen, in dendritic cells.
Hypocrellin A also inhibited the cytosolic pathway of endogenous antigen presentation. However, hypocrellin A did not inhibit the expression of class I and class II MHC molecules on dendritic cells (DCs), the phagocytic activity of DCs, or the H-2Kb-restricted presentation of a synthetic peptide, SIINFEKL.
These results show that hypocrellin A differentially modulates the MHC-restricted antigen presentation pathways.

참고문헌 (Reference)

1 Park J, "The role of oxygen in the antiviral activity of hypericin and hypocrellin" 68 : 593-597, 1998

2 Daub ME, "The photoactivated cercospora toxin cercosporin: Contributions to Plant Disease and Fundamental Biology" 38 : 461-490, 2000

3 Groothuis TA, "The many roads to crosspresentation" 202 : 1313-1318, 2005

4 He YY, "Synthesis and EPR investigations of new aminated hypocrellin derivatives" 28 : 1642-1651, 2000

5 Ma L, "Photodynamic inhibitory effects of three perylenequinones on human colorectal carcinoma cell line and primate embryonic stem cell line" 9 : 485-490, 2003

6 Harding CV, "Phagocytic processing of antigens for presentation by MHC molecules" 5 : 105-109, 1995

7 Diwu Z, "Novel therapeutic and diagnostic applications of hypocrellins and hypericins" 61 : 529-539, 1995

8 Liang XH, "Isolation and identification of a new hypocrellin A-producing strain Shiraia sp. SUPER-H168" 164 : 9-17, 2009

9 Ali SM,Chee SK, "Hypocrellins and hypericin induced apoptosis in human tumor cells: a possible role of hydrogen peroxide" 9 : 461-472, 2002

10 Ma JS, "Hypocrellin-A sensitized photooxidation of bilirubin" 50 : 827-830, 1989

11 Wan XY, "Hypocrellin A, a new drug for photochemotherapy" 26 : 1040-1041, 1981

12 Ojcius DM, "Dissociation of the peptide/ MHC class I complex: pH dependence and effect of endogenous peptides on the activation energy" 197 : 1216-1222, 1993

13 Diwu Z, "Design, synthesis and investigation of mechanisms of action of novel protein kinase C inhibitors: perylenequinonoid pigments" 47 : 373-385, 1994

14 Turmunkh Gerelchuluun, "Dendritic Cells Process Antigens Encapsulated in a Biodegradable Polymer, Poly(D,L-lactide-co-glycolide), via an Alternate Class I MHC Processing Pathway" 대한약학회 30 (30): 1440-1446, 2007

15 Lee YR, "Cyclosporin A and tacrolimus, but not rapamycin, inhibit MHC-restricted antigen presentation pathways in dendritic cells" AMER SOC HEMATOLOGY 105 : 3951-3955, 200505

16 Carbone FR, "Cross-presentation: a general mechanism for CTL immunity and tolerance" 19 : 368-373, 1998

17 Heath WR, "Cross-presentation, dendritic cells, tolerance and immunity" 19 : 47-64, 2001

18 Ackerman AL, "Cellular mechanisms governing cross-presentation of exogenous antigens" 5 : 678-684, 2004

19 Lee YH, "Baccatin III, a synthetic precursor of taxol, enhances MHC-restricted antigen presentation in dendritic cells" 11 : 985-991, 2011

20 Ma G, "Antimicrobial and antileishmanial activities of hypocrellins A and B" 48 : 4450-4452, 2004

21 Schinazi RF, "Anthraquinones as a new class of antiviral agents against human immunodeficiency virus" 13 : 265-272, 1990

22 Kovacsovics-Bankowski M, "A phagosome-to- cytosol pathway for exogenous antigens presented on MHC class I molecules" 267 : 243-246, 1995