쇼그렌 증후군에 동반된 원위신세관산증 2예

다국어 초록 (Multilingual Abstract)

Renal tubular acidosis (RTA) is a syndrome characterized by hyperchloremic metabolic acidosis and an inability to excrete a highly acid urine, in which impairment of acid excretion is out of proportion to reduction of glomerular filtration rate. Distal renal tubular acidosis (dRTA) is frequently associated with immune-mediated disease including Sjigren’s syndrome. Sjigren’s syndrome is a systemic autoimmune disease that mainly affects the exocrine glands such as lacrimal and salivary glands, resulting in xerophtalmia and xerostomia. Extrglandular manifestations are frequent and may include renal involvement. Recently, we experienced two cases of renal tubular acidosis in Sjigren’s syndrome. The 1st case was a patient who had lower extremities weakness and hypokalemia, and the 2nd case was a patient who had nephrocalcinosis. We discussed the frequencies and the pathogenesis of dRTA in Sjigren’s syndrome. Keywords: Sjigren’s syndrome; Distal renal tubular acidosis; Hypokalemia; Nephrocalcinosis