RISS 검색 - 국내학술지논문 상세보기

부가정보

다국어 초록 (Multilingual Abstract)

Background
On COVID-19 pandemic, patients who have respiratory symptoms have less access to hospital and early treatment is difficult. We investigated the clinical impact of COVID-19 on management in patients with tuberculosis in a longitudinal cohort analysis.
Methods
This study was conducted retrospectively in Seoul St. Mary hospital between January 2019 and December 2020. Among 500 TB subjects, 52 patients who did not take an initial diagnosis with TB in our hospital were excluded.
Results
Out of 448 patients, 267 (59.6%) were diagnosed as TB in 2019 and 181 (40.4%) were diagnosed in 2020. The duration of from symptom onset to diagnosis was not distinctive between in both group. But the proportion of hospital admission related with TB infection increased after COVID-19 epidemic (38.7% vs 62.4%, p <.0001). We further analyzed in subgroups diagnosed with pulmonary TB. The patients with pulmonary TB were higher in 2019 than in 2020 (59.12% vs 40.88%, p< 0001). The average age, history of tuberculosis were similar between two groups. The portion of having underlying diseases was increased in the 2020 group with pulmonary TB (59.04% in 2019 vs 70.77% in 2020, p= 0.0398). The percentage of AFB stain positivity and TB involved area in chest X-ray were higher and more severe in the 2020 group, diagnosed with pulmonary TB after COVID-19 pandemic. TB treatment outcome was contrasting between two groups. Favorable outcome including cure or completion of TB showed higher in the 2019 than in the 2020 (Cure, 12.5% vs 10%, p= 0.0027; treatment completion, 65.9% vs 50%, p=0.0027).
Conclusions
In pulmonary TB, higher mycobacterial TB burden, more extensive area of TB in Chest X-ray, lower rate of treatment outcome were revealed in the 2020 patients than in the 2019, suggesting that COVID-19 pandemic affected detrimental to the patients’ care with TB infection.