제 2형 당뇨환자에서 Lipocalin-2, A-FAPB와 뇨 알부민 배출과의 연관성

다국어 초록 (Multilingual Abstract)

Background: Lipocalin family proteins including lipocalin-2, adipocyte fatty acid binding protein (A-FABP), and retinol binding protein 4 have recently been identified as novel adipokines linked to obesity-induced insulin resistance and type 2 diabetes.
Methods: Study design is a cross-sectional study. The study subjects comprised 89 patients with type 2 diabetes and 45 age-, gender- and BMI-matched non-diabetic controls. Factors are urinary albumin excretion (UAE), estimated glomerular filtration rate (eGFR) and high sensitivity C-reactive protein (hsCRP). Outcomes are Lipocalin-2 and A-FABP levels. UAE was measured using 24 h urine samples and eGFR was calculated using the equation of the Modification Diet in Renal Disease Study. Lipocalin-2 and A-FABP levels were measured using ELISA.
Results: Circulating lipocalin-2 levels were significantly higher (19.2 ± 7.3 ng/ml vs. 13.9 ± 3.9 ng/ml, P <0.001) in patients with type 2 diabetes compared to non-diabetic subjects, whereas A-FABP levels showed a tendency to be higher in type 2 diabetic patients (6.2 ± 3.0 vs. 5.3 ± 2.3 ng/ml, P = 0.089). Simple regression analysis revealed that waist circumference, systolic blood pressure, glucose, HOMA-IR(the Homeostasis Model Assessment-Insulin Resistance), creatinine, hsCRP, and UAE levels were positively correlated with serum lipocalin-2 levels. In contrast, lipocalin-2 levels were negatively correlated with HDL cholesterol and eGFR levels. However, A-FABP levels were not significantly related with UAE. In multiple regression analysis, lipocalin-2 was independently associated with creatinine, hsCRP, and UAE (R² = 0.391).
Conclusions: Serum lipocalin-2 levels were significantly elevated in patients with type 2 diabetes and were independently associated with UAE and inflammation.

목차 (Table of Contents)

• ABSTRACT = 4
• 연구방법 = 11
• 결과 = 15
• 고찰 = 18
• REFERENCES = 23