인진호 추출물의 건선 유발 각질세포에서 항염 효과 = Anti-inflammatory Effect of Artemisiae Capillaris Herba Extracts in Psoriasis-induced Keratinocytes

다국어 초록 (Multilingual Abstract)

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다국어 초록 (Multilingual Abstract)

In the current study, we examined the effects of Artemisiae Capillaris Herba extracts (ACH) on the anti- inflammatory efficacy in keratinocytes. HaCaT keratinocytes were stimulated with M5 (mixture of IL-17A, IL-22, IL-1α, oncostatin M, and TNF-α) for development of a psoriatic keratinocyte model in vitro. Stimulation with M5 resulted in significantly upregulated levels of TNF-α, IL-1β, CCL-20, and CXCL-8. However, upregulation of these inflammatory cytokines and chemokines was attenuated by treatment with ACH. In addition, phosphorylation of MAPKs, JAK1/2 and STAT1/3 was inhibited by ACH in psoriatic keratinocytes. These findings suggest the potential for future use of ACH as a natural cosmetic material.

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