Ultrasonic cavitation bubble- and gas bubble-assisted adsorption of paclitaxel from Taxus chinensis onto Sylopute

다국어 초록 (Multilingual Abstract)

This study presents a technique for adsorption of paclitaxel on Sylopute using ultrasonic cavitation bubbles and gas bubbles. Compared with the conventional adsorption (control), the adsorbed amount and adsorption rate constant increased, respectively, by 1.27-1.44 times and 7.44-9.71 times in ultrasonic adsorption (with mixing at 80-250W), 1.14-1.27 times and 4.63-9.31 times in ultrasonic adsorption (without mixing at 80-250 W), and 1.06-1.19 times and 1.18-1.34 times in gas bubble-adsorption (without mixing at 1.15-9.41 L/min). As a result of investigating the adsorption mechanism in which cavitation bubbles were introduced, it was shown that microjets and shock waves produced by bubble collapse, rather than the bubble itself, drastically improve mass transport in the pores of the adsorbent, thereby completely eliminating intraparticle diffusion resistance. In the case of gas bubbles, although the intraparticle diffusion coefficient increased by 1.34-1.75 times compared with the control, there was a limitation in promoting intraparticle diffusion.

참고문헌 (Reference)

1 A. M. L. Seca, 19 : 263-, 2018

2 K. Wohlgemuth, 64 : 4155-, 2009

3 L. Wolloch, 148 : 204-, 2010

4 H. S. Shin, 51 : 917-, 2016

5 J. B. Ji, 13 : 463-, 2006

6 M. Ondarts, 343 : 163-, 2018

7 Y. S. Kim, 130 : 104-, 2019

8 R. Krishna, 87 : 455-, 2000

9 S. H. Pyo, 1123 : 15-, 2006

10 H. W. Seo, 87 : 238-, 2019

11 S. H. Pyo, 39 : 1985-, 2004

12 Y. S. Lim, 115 : 261-, 2017

13 O. Hamdaoui, 10 : 109-, 2003

14 O. Hamdaoui, 16 : 15-, 2009

15 B. S. Schueller, 40 : 4912-, 2001

16 X. Zhou, 160 : 332-, 2016

17 J. Y. Lee, 103 : 8-, 2013

18 H. S. Kim, 56 : 163-, 2017

19 P. Maneechakr, 106 : 104-, 2017

20 O. Hamdaoui, 15 : 799-, 2008

21 F. C. Wu, 283 : 49-, 2005

22 조다님, "실로퓨트에 의한 아세나프텐 흡착에 관한 등온흡착식, 동역학 및 열역학적 특성" 한국화학공학회 58 (58): 127-134, 2020

23 박세훈, "실로퓨트에 의한 Taxus chinensis 유래 7-에피-10-디아세틸파클리탁셀의 흡착에 대한 평형, 등온흡착식, 동역학 및 열역학적 특성" 한국화학공학회 58 (58): 113-121, 2020

24 이충기, "식물세포배양으로부터 파클리탁셀 및 이의 반합성 전구체 10-디아세틸파클리탁셀의 분리 양상" 한국화학공학회 54 (54): 89-93, 2016

25 강회종, "Removal of residual chloroform from amorphous paclitaxel pretreated by alcohol" 한국화학공학회 36 (36): 1965-1970, 2019

26 Hoe-Jong Kang, "Removal of Residual Toluene and Methyl Tertiary Butyl Ether from Amorphous Paclitaxel by Simple Rotary Evaporation with Alcohol Pretreatment" 한국생물공학회 25 (25): 86-93, 2020

27 유경완, "Kinetics and Mechanism of Ultrasound-assisted Extraction of Paclitaxel from Taxus chinensis" 한국생물공학회 23 (23): 532-540, 2018

28 Hoe-Jong Kang, "Adsorption Kinetics, Mechanism, Isotherm, and Thermodynamic Analysis of Paclitaxel from Extracts of Taxus chinensis Cell Cultures onto Sylopute" 한국생물공학회 24 (24): 513-521, 2019