Antinociceptive Efficacy of Korean Bee Venom in the Abdominal Pain of the Mouse

다국어 초록 (Multilingual Abstract)

This study was undertaken to assess the antinociceptive effect of Korean bee venom (BV) in mice. Koreanelectrical impulse is used to stimulate the worker bee (Apismellifera L.) to sting and release venom. After collection, whole BV was evaporated until dry using the BV collector.Experiments were performed on male ICR mice (weighing 30~35 g, 6 weeks old). Mice were divided into 4 groups,each comprising 8 mice. BV was diluted and amounts of 6 mg/kg body weight (BW), 0.6 mg/kg BW and 0.06 mg/kg BW were tested. BV was subcutaneously injected to produce an antinociceptive effect and the antinociceptive efficacywas evaluated using a writhing test in mice. Intraperitoneal injection of acetic acid produced a tonic pain behavior,then declined until it was undetectable at 60 min post-injection. The time elapse between the administration of aceticacid and the first observed pain behaviors indicated a dose-dependent suppresive effect. These results suggest thatKorean BV may be used to achieve an antinociceptive effect for use in medical therapies.

참고문헌 (Reference)

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