Non-Alcoholic Fatty Liver Disease: The New Epidemic and the Need for Novel Nutritional Approaches

다국어 초록 (Multilingual Abstract)

The epidemic of non-alcoholic fatty liver disease (NAFLD) in the United States is staggering, and there is anenormous void in our understanding of the clinical epidemiology other than the common themes of obesity and insulin re-and appropriate nutritional supplements. There is, however, a wealth of basic science that helps to set the stage for definingthe mechanisms leading to liver pathology. In this article we will attempt to put these concepts in perspective to highlight theneed for future research including the use of medicinal food.

참고문헌 (Reference)

1 Honda M, "cDNA microarray analysis of autoimmune hepatitis, primary biliary cirrhosis and consecutive disease manifestation" 25 : 133-140, 2005

2 Harrison SA, "Vitamin E and vitamin C treatment improves fibrosis in patients with nonalcoholic steatohepatitis" 998 : 2485-2490, 2003

3 Clark JM, "The prevalence and etiology of elevated aminotransferase levels in the United States" 98 : 960-967, 2003

4 Senthilkumar R, "The potential beneficial effect of glycine on the carbohydrate moieties of glycoproteins in an experimental model of alcohol-induced hepatotoxicity" 7 : 108-113, 2004

5 Hahn BH, "The pathogenesis of atherosclerosis in autoimmune rheumatic diseases: roles of inflammation and dyslipidemia" 28 : 69-75, 2007

6 Selmi C, "The immunological milieu of the liver" 27 : 129-139, 2007

7 Fujioka K, "The effects of grapefruit on weight and insulin resistance: relationship to the metabolic syndrome" 9 : 49-54, 2006

8 Trinidad TP, "The cholesterol-lowering effect of coconut flakes in humans with moderately raised serum cholesterol" 7 : 136-140, 2004

9 Kim WR, "The burden of hepatitis C in the United States" 36 (36): 30-34, 2002

10 Endo M, "TNF-alpha induces hepatic steatosis in mice by enhancing gene expression of sterol regulatory element binding protein-1c (SREBP-1c)" 232 : 614-621, 2007

11 Day CP, "Steatohepatitis: a tale of two “hits”?" 114 : 842-845, 1998

12 Li Z, "Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease" 37 : 343-350, 2003

13 Sakaguchi S, "Preventive effects of a traditional Chinese medicine (Sho-saiko-to) on endotoxin-induced cytotoxicity and tumor necrosis factor-alpha production in J774A.1 cells" 27 : 1468-1470, 2004

14 Flegal KM, "Prevalence and trends in obesity among US adults, 1999, 2000." 288 : 1723-1727, 2002

15 Salunga TL, "Oxidative stress-induced apoptosis of bile duct cells in primary biliary cirrhosis" 29 : 78-86, 2007

16 Farrell GC, "Nonalcoholic fatty liver disease: from steatosis to cirrhosis" 43 : 99-112, 2006

17 "NON-ALCOHOLIC FATTY LIVER DISEASE 565 Downloaded by"

18 Vgontzas AN, "Marked decrease in sleepiness in patients with sleep apnea by etanercept, a tumor necrosis factor-alpha antagonist" 89 : 4409-4413, 2004

19 Ramesh B, "Influence of sesame oil on blood glucose, lipid peroxidation, and antioxidant status in streptozotocin diabetic rats" 8 : 377-381, 2005

20 Samuels R, "Hypocholesterolemic effect of Spirulina in patients with hyperlipidemic nephrotic syndrome" 5 : 91-96, 2002

21 Rukkumani R, "Hepatoprotective role of ferulic acid: a dose-dependent study" 7 : 456-461, 2004

22 Gilliam LK, "Evaluation of leptin levels in subjects at risk for type 1 diabetes" 26 : 133-137, 2006

23 Alter MJ, "Epidemiology of hepatitis B in Europe and worldwide" 39 (39): 64-69, 2003

24 Kugelmas M, "Cytokines and NASH: a pilot study of the effects of lifestyle modification and vitamin E" 38 : 413-419, 2003

25 Manco M, "Correlation of serum TNF-alpha levels and histologic liver injury scores in pediatric nonalcoholic fatty liver disease" 127 : 954-960, 2007

26 Esmaillzadeh A, "Concentrated pomegranate juice improves lipid profiles in diabetic patients with hyperlipidemia" 7 : 305-308, 2004

27 Zheng R, "Characterization and immunomodulating activities of polysaccharide from Lentinus edodes" 5 : 811-820, 2005

28 Sandhya VG, "Beneficial effects of coconut water feeding on lipid metabolism in cholesterol-fed rats" 9 : 400-407, 2006

29 Abbas AK, "Balancing autoaggressive and protective T cell responses" 28 : 59-61, 2007

30 Musso G, "Adipokines in NASH: postprandial lipid metabolism as a link between adiponectin and liver disease" 42 : 1175-1183, 2005