Anti-inflammatory Activity of Some Potassium Salts of N,N-Disubstituted 4-Aminoazobenzenesulfonic Acids in Rat Adjuvant Arthritis

다국어 초록 (Multilingual Abstract)

Anti-inflammatory effects of three potassium salts of N,N-disubstituted 4-aminoazobenzenesulfonic
acids were investigated and compared to that of acetylsalicylic acid (ASA) in rats with
adjuvant arthritis (AA). Prophylactic oral administration of all compounds in a dose of 150 mg/
kg ameliorated AA symptoms in animals. The most pronounced anti-inflammatory activity at
the end of the experiment showed compound 1 containing imino group: it significantly suppressed
joint swelling by 48.2% in female and by 44.2% in male rats with AA. The development
of polyarthritis after the treatment with this compound was the lowest in female (20%)
and male (40%) rats (in control – 100% of animals with polyarthritis). All derivatives, and especially
compound 1, also improved the systemic parameters of disease such as blood indices
and internal organs’ weight, and showed no toxicity on the main organs such as liver and
spleen.

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