<P><I>Lespedeza </I>has been used for the management of diabetes in folklore medicine. The purpose of this study is to investigate the protective effects of the methanol extract of<I> Lespedeza davurica</I> (LD) on cytoki...
http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
https://www.riss.kr/link?id=A107476273
2015
-
SCOPUS
학술저널
169256
0
상세조회0
다운로드다국어 초록 (Multilingual Abstract)
<P><I>Lespedeza </I>has been used for the management of diabetes in folklore medicine. The purpose of this study is to investigate the protective effects of the methanol extract of<I> Lespedeza davurica</I> (LD) on cytoki...
<P><I>Lespedeza </I>has been used for the management of diabetes in folklore medicine. The purpose of this study is to investigate the protective effects of the methanol extract of<I> Lespedeza davurica</I> (LD) on cytokine-induced <I>β</I>-cell damage and streptozotocin- (STZ-) induced diabetes. RINm5F cells were treated with interleukin- (IL-) 1<I>β</I> and interferon- (IFN-) <I>γ</I> to induce pancreatic <I>β</I>-cell damage. The exposure of LD extract significantly decreased cell death, nitric oxide (NO) production, nitric oxide synthase (iNOS) expression, and nucleus factor-kappa B (NF-<I>κ</I>B) p65 activation. Antidiabetic effects of LD extract were observed by oral glucose tolerance test (OGTT) in normal rats and by checking the biochemical, physiological, and histopathological parameters in STZ-induced diabetic rats. In OGTT, glucose clearance levels improved by oral treatment of LD extract. The water intake, urine volume, blood glucose, and serum TG, TC, TBARS, and DPP-IV levels were significantly decreased, and liver glycogen content was significantly increased by treatment of LD extract (250 mg/kg BW) in STZ-induced diabetic rats. Also, insulin immunoreactivity of the pancreases was increased in LD extract administrated rats compared with diabetic control rats. These results indicate that LD extract may protect pancreatic <I>β</I>-cell damage and regulate the blood glucose in STZ-induced diabetic rats.</P>
Genetic Polymorphism in Extracellular Regulators of Wnt Signaling Pathway