癩患者의 血淸 Testosterone値

다국어 초록 (Multilingual Abstract)

Testicular involvement in male patients with leprosy is well documented and may be associated with impotence, sterility and gynecomastia. Testicular histology shows atrophy of the seminiferous tubules with hypertropy and clumping of Leydig cells and hyalinization of the small and medium sized vessels. The hormonal functions of the testes have been studied by a number of 'workers, usually in patients‘
with testicular atrophy and gynecomastia. In these particular patients, androgens are generally diminished while gonadotropins are increased. The pathogenesis of testicular damage is uncertain, though Wall and Wright (1974) found that testicular germinal cell antibodies were present in 75 % of lepromatous, and postulated that .autoimmunity, Erythema Nodosum Leprosum immune complex damage and direct invasion by Mycobacterium leprae may all be contributory.
The author studied the serum testosterone levels in male patients with leprosy (twenty-five with lepromatous type and . twenty-five with tuberculoid type) and twenty-five normal healthy controls by double-antibody .method of radioimmunoas:
say. Comparative studies of testosterone levels in these two types of leprosy and relationships among the degree of testicular atrophy, gynecomastia, duration of treatment and age were also conducted. The results were summarized as follows:
Ages of the selected patients were between 27 to 72 years in lepromatous leprosy (average 47.4), 29 to 75 years in tuberculoid leprosy(average 48.4) and 24 to 73years in the control group (average 43. 6). The duration of treatment in lepromatous leprosy was between 6 and 33 years and the averagewas 13.6 years. Of tuberculoid leprosy, duration of treatment was between 6 and 38 years and the average was 19 years.
The mean serum testosterone level in lepromatous leprosy patients was 1. 212ng/ml, which was significantly lower than that of both the tuberculoid lep-rosy, 4. 112ng/ml(+1. 807) (p<0.001), and the normal healthy control group,
4. 535ng/ml (+2.343) (p<0.001). There were no significant differences of serum testosterone levels between the tuberculoid leprosy group and the normal healthy.control group.
Gynecomastia was seen in 64% of the lepromatous leprosy group, 12% of the tuberculoid leprosy group and testicular atrophy was seen in 64 % of the lepromat ous leprosy group and 20 % in the tuberculoid leprosy group.
In the lepromatous leprosy group with gynecomastia, the serum testosterone level was significantly lower than that of the control group (p<0.001), however no significant differences of serum testosterone levels were noted between the lepromat-ous leprosy group with gynecomastia and without gynecomastia (p> 0.1).
No significant meaning was found in the serum testosterone level in both lepromatous leprosy groups with or without 'gynecomastia or testicular atrophied groups.
There was no correlation between age and serum testosterone levels in the lepr-omatous leprosy and control groups, but the serum testosterone levels increases according to the increase of age in tuberculoid leprosy.
There was no relationship between the duration of dapsone treatment and serum testosterone level in both the tuberculoid and lepromatous leprosy groups.

목차 (Table of Contents)

• Abstract 1
• 序論 2
• 材料 및 方法 3
• 成績 3
• 總括 및 考按 6
• 結論 8
• 參考文獻 8