Mitogen Activated Protein Kinase Family Proteins and c-jun Signaling in Injury-induced Schwann Cell Plasticity

다국어 초록 (Multilingual Abstract)

Schwann cells (SCs) in the peripheral nerves myelinate axons during postnatal development to allow saltatory conduction of nerveimpulses. Well-organized structures of myelin sheathes are maintained throughout life unless nerves are insulted. After peripheralnerve injury, unidentified signals from injured nerves drive SC dedifferentiation into an immature state. Dedifferentiated SCsparticipate in axonal regeneration by producing neurotrophic factors and removing degenerating nerve debris. In this review, wefocus on the role of mitogen activated protein kinase family proteins (MAP kinases) in SC dedifferentiation. In addition, we willhighlight neuregulin 1 and the transcription factor c-jun as upstream and downstream signals for MAP kinases in SC responses tonerve injury.

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