관리용액 점안이 소프트콘택트렌즈를 착용한 건성안의 눈물막 안정성에 미치는 영향

다국어 초록 (Multilingual Abstract)

Purpose: This study investigated the usage of lens care solution as an eye drop, the perception of lens care solution instillation, and the effects of lens care solution instillation on tear film stability and subjective symptoms of soft contact lens wearers with dry eyes. Methods: To investigate the actual usage of lens care solution as an eye drop and the perception of lens care solution instillation, an online survey was conducted on lens wearers who had no expert lens knowledge. Artificial tear and lens care solutions (2 multipurpose solutions and 1 wetting solution) were applied to contact lens wearers with dry eyes and their NIBUT and blink rate were measured. A survey was conducted to investigate the subjective symptoms following instillation. Results: More than a few lens wearers have used lens care solution as an eye drop, which isnt its original use, or had a positive perception of lens care solution instillation. A large number of respondents didnt know the exact direction for use of the lens care solution. NIBUT increased immediately after the instillation of artificial tear and lens care solutions yet decreased after 15 ~ 20 minutes following lens care solution instillation. All four solutions showed little effect on the change of blink rate after instillation. Although most subjective symptoms improved after artificial tear instillation, they worsened after instillation of multipurpose solutions. Conclusions: Lens care solutions are less effective in maintaining tear film stability than artificial tears and exacerbate subjective symptoms. Therefore, artificial tear instillation is the most effective and safe for dry eyes. In addition, lens wearers need to be educated on proper use of lens care solutions.

참고문헌 (Reference)

1 최태훈, "한국 콘택트렌즈 실태조사" 대한안과학회 45 (45): 9-9, 2004

2 최지영, "제주지역 여대생들의 콘택트렌즈 착용 및 관리 실태와 눈건강 인식" 한국안광학회 21 (21): 203-214, 2016

3 정다이, "정상안과 건성안에서 소프트렌즈 피팅 상태에 따른 비침입성 눈물막 파괴 시간의 차이" 한국안광학회 15 (15): 339-346, 2010

4 신혜민, "인공눈물의 주성분 차이가 소프트렌즈 착용자의 눈물막안정성에 미치는 영향" 한국안광학회 21 (21): 351-360, 2016

5 김남열, "이미지 분석법을 이용한 소프트 콘택트렌즈용 다목적용액의각막상피세포 독성 평가" 한국안광학회 20 (20): 51-60, 2015

6 김소라, "소프트콘택트렌즈를 착용한 건성안의 착용초기 눈물막안정성에 인공눈물 성분 조성이 미치는 영향" 한국안광학회 21 (21): 191-201, 2016

7 김판상, "설문을 통한 청소년기 학생들의 콘택트렌즈 사용실태조사" 대한안과학회 55 (55): 54-58, 2014

8 윤철민, "대학생을 대상으로 실시한 건성안 유병률 조사" 대한안과학회 53 (53): 505-509, 2012

9 서성관, "건성안에서 인공누액제 점안이 중심각막두께에 미치는 영향" 대한안과학회 50 (50): 1483-1488, 2009

10 Zhao M, "Poloxamines for deswelling of organ-cultured corneas" 48 (48): 124-133, 2012

11 Moghimi SM, "Poloxamers and poloxamines in nanoparticle engineering and experimental medicine" 18 (18): 412-420, 2000

12 Neal JC, "Modification of the copolymers poloxamer 407 and poloxamine 908 can affect the physical and biological properties of surface modified nanospheres" 15 (15): 318-324, 1998

13 Al Khateb K, "In situ gelling systems based on Pluronic F127/Pluronic F68 formulations for ocular drug delivery" 502 (502): 70-79, 2016

14 Nayak VS, "Evaporative light scattering detection based HPLC method for the determination of polysorbate 80 in therapeutic protein formulations" 50 (50): 21-25, 2012

15 Ho L, "Effect of age on ocular irritancy as measured with in vitro bovine lenses" 22 (22): 450-456, 2008

16 Brewitt H, "Dry eye disease: the scale of the problem" 45 (45): S199-S202, 2001

17 Price R, "Comparison of silk-elastinlike protein polymer hydrogel and poloxamer in matrix-mediated gene delivery" 427 (427): 97-104, 2012

18 Tong L, "Choice of artificial tear formulation for patients with dry eye: where do we start?" 31 (31): S32-S36, 2012

19 Ayaki M, "Cell viability of four corneoconjunctival cell lines exposed to five preservatives and a surfactant used for infection control in eyedrops" 16 (16): 117-121, 2011