조직병리학 및 Histomorphometry 기법으로 관찰한 종양 유발 마우스의 주요 장기에 인진쑥 Methanol 추출물이 미치는 영향 = Effects of Artemisia capillaris Methanol Extract on Organs in Tumor Cells Inoculated Mice Observed the Histopathology and Histomorphometry

다국어 초록 (Multilingual Abstract)

This experiment was conducted to investigate antitumor and immunomodulatory effects of Artemisia
capillaris extracts against Hepa-1c1c7 and Sarcoma 180 cancer cells. In in vivo experimental tests using 210 ICR
mice, on the 28th day and the 42nd day, all animals in vehicle controled HP (Hepa-1c1c7 tumor cell inoculated vehicle
control) and SP (Sarcoma 180 tumor cell inoculated vehicle control) showed tumor cells in the liver and spleen based
on the histopathology. However, the incidences and the percentages of regions occupied by tumor cells were dramatically
and dose-dependently decreased by mACH (Artemisia capillaris methanol extracts) treatment on the histomorphometry.
Although the exact mechanism of inhibition of the incidences of tumor cells in the parenchyma whether inhibition
of metastasis or proliferation is unclear, mACH dramatically reduce the percentages of regions occupied by tumor
cells in the liver and spleen apart from the inoculation sites of Hepa-1c1c7 and Sarcoma 180. In addition, they also
effectively inhibit the abnormal changes on the kidney detected in the present study. The results suggest that Artemisia
capillaris methanol extracts have prominent antitumor effects on the cancer cell lines Hepa-1c1c7 and Sarcoma 180
in mice.

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