Relationships among the Performances of Naming, Discourse Production and IADL in Amnestic MCI

국문 초록 (Abstract)

배경 및 목적: 도구적 일상생활 능력(instrumental ability of daily living, IADL)의 제한은 치매 발병 이전 단계인 경도인지장애(mild cognitive impairment, MCI) 환자에게도 나타나는 것으로 알려져 있다. 본 연구에서는 알츠하이머형 치매로 발전할 가능성이 높은 기억상실형 MCI (amnestic MCI, aMCI) 환자의 이름대기 및 담화산출 능력과 IADL 사이의 관련성을 살펴보았다. 방법: 본 연구는 aMCI 환자 50명을 대상으로 하였다. 이름대기 능력은 대면이름대기(Korean-Boston Naming Test, K-BNT)와 구어유창성 검사(의미, 음운)를 사용하였으며, 담화산출 능력은 그림설명을 통한 CIU (correct information unit) 비율로 측정하였다. IADL은 한국판 Lawton IADL검사를 사용하여 평가하였다. 결과: 첫째, aMCI 환자의 IADL은 연령 및 교육년수와는 유의한 상관이 나타나지 않았으며, 한국판 간이정신상태검사(Korean version of Mini-Mental Examination) 점수와 IADL 사이에는 유의한 상관이 있었다. 둘째, aMCI 환자의 IADL은 K-BNT 및 음운적 구어유창성 과제의 수행과는 유의한 상관이 나타나지 않았으나, 의미적 구어유창성 과제의 수행과 CIU 비율과는 유의한 상관을 보였다. 셋째, 회귀분석 결과 의미적 구어유창성 과제의 수행과 CIU 비율은 aMCI 환자의 IALD에 영향을 미치는 것으로 나타났다. 논의 및 결론: 이러한 결과는 aMCI 환자의 의미적 구어유창성 및 담화산출 능력과 IADL 사이에 관련성이 있음을 시사한다.

다국어 초록 (Multilingual Abstract)

Objectives: The limitations of the Instrumental Ability of Daily Living (IADL) are known to appear not only in patients with dementia of Alzheimer’s type, but also in patients with amnestic mild cognitive impairment (aMCI). The purpose of this study was to investigate the relationship between IADL and the ability of naming and discourse production in patients with aMCI. Methods: Fifty patients with aMCI participated in this study. The naming tests included confrontational naming (Korean version of Boston Naming Test [K-BNT]) and verbal fluency (semantics & phonemics). Discourse samples were collected from picture description tasks. IADL was assessed using the Korean version Lawton IADL test. Results: First, performances of IADL in patients with aMCI were not significantly correlated with age and education level. However, there was a significant correlation between the Korean version of the Mini-Mental Examination (K-MMSE) score and IADL. Second, performances of IADL in patients with aMCI were not significantly correlated with the performances of the K-BNT and phonemic fluency task. However, the performance of the semantic fluency task and correct information unit (CIU) ratio showed a significant correlation with IADL in patients with aMCI. Third, regression analysis revealed that the performance of the semantic fluency task and the CIU ratio affected the IALD of patients with aMCI. Conclusion: These results suggest that there is a relationship between performances of semantic fluency, discourse production and IADL in patients with aMCI.

목차 (Table of Contents)

• 연구방법 연구결과 논의 및 결론

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