DMSO 용매를 활용한 퀴놀론의 친환경적인 합성법 개발

다국어 초록 (Multilingual Abstract)

Quinolone motifs are widespread in various biologically active natural and pharmaceutical compounds. Previously, a reagent-free synthesis of flavones from o-alkynoylphenols has been developed with DMSO promotion. In this regard, o-alkynoyl aniline was tested, and both 5-exo and 6-endo cyclized rings were observed. The conditions were slightly modified, and quinolones were successfully achieved via 6-endo cyclization. The developed method tolerates various functional groups and yields the corresponding quinolones. A reagent- free, operationally simple, highly atom-economic, environmentally benign, and mild- conditioned method has been developed for synthesizing quinolones. This method will be useful for the synthesis of biologically active compounds, including 4-quimolone motif structure. * A thesis for the degree of Master of science in Pharmacy in February 2024

목차 (Table of Contents)

• List of Figures ii
• List of Tables . ii
• List of Schemes ii
• List of Abbreviations iii
• Abstract v
• Ⅰ. 서 론 1
• Ⅱ. 본 론 5
• 1. 합성 설계 . 5
• 2. 합성. 8
• Ⅲ. 결 론 17
• Ⅳ. 실 험 18
• 1. 측정기기 및 시약 .18
• 2. 합성 방법 19
• Ⅴ. 참고 문헌 35
• Ⅵ. 부 록 38