심부전에서 세포치료의 전망 = The Future of Cell-based Therapy for Heart Failure

다국어 초록 (Multilingual Abstract)

Cardiac repair is a dream of medical science field. The biological limitations to human cardiac regenerative growth create new strategies for cardiac regeneration using cells, genes and protein. Recent experimental studies and early-phase clinical trials showed stem cells have the potential to enhance myocardial perfusion and contractile performance in patients with acute myocardial infarction, advanced coronary artery disease, and chronic heart failure. The overall clinical experience also suggests that stem cell therapy can be safely performed, if the right cell protocol is used in the right clinical setting. Some experimental data showed stable stem cell engraftment by fusion or transdifferentiation into cardiomyocyte or vascular cell lineages as likely explanations for these beneficial effects. Others have proposed that transient cell retention may be sufficient to promote functional effects, e.g., by release of paracrine mediators. We should proceed cautiously with carefully designed clinical trials and concern that patient safety must remain the key issue. The translantional basic research to elucidate the mechanism of stem cell therapy is necessary.