Hormonal Effects on the Serum Haptoglobin Level in Rabbits = 토끼의 혈청 Haptoglobin 농도에 미치는 홀몬의 영향

국문 초록 (Abstract)

토끼에 terpentine 유를 주사하면 저명하게 혈청 haptoglobin이 증가한다는 것은 이미 잘 알려진 사실이다 (Murray and Connell, 1960; 金, 1961b). 사람에서는 각종 감염증, 악성종양, 결핵성질환 때에 혈청 haptoglobin 농도가 상승하며 (金, 羅, 1963) cortisone 투여도 혈청 haptoglobin을 상승 시킨다. (金,1961a).
이와같은 고 haptoglobin 혈증의 발생 기전을 연구할 목적으로 池(1968)는 histamine, epinephrine,norepinephrine, acetylcholine 등을 토끼에 주사한바 극히 미약하게 혈청 haptoglobin이 증가함을 관찰하였다.

다국어 초록 (Multilingual Abstract)

To elucidate the mechanism of hyperhaptoglobinemia in the experimental inflammation by terpentine, the effects of several hormones (estradiol, progesterone, testosterone, ACTH, prednisolone or adrenalectomy) on serum haptoglobin level were investigated in rabbits. Sex hormones did not show any effect on serum haptoglobin level, while they reduced the clearance rate of mobilized haptoglobin by terpentine from the systemic circulation. ACTH and prednisolone showed little effect. Stresses involving subcutaneous tissue injury such as simple laparatomy or subcutaneous administration of terpentine have induced marked increase in serum haptoglobin level. These observations suggest the possible role of adrenal cortex in the production of hyperhaptoglobinemia which is not mediated through pituitary corticotropin.