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Extra‐nodal marginal zone B‐cell lymphoma (MZBL) of mucosa‐associated lymphoid tissue is an indolent lymphoma mostly affecting the gastrointestinal tract. The lymphoma initially has small‐cell morphology (SC‐MZBL) and often arises in the bac...
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RISS 인기검색어
Genome‐wide DNA methylation analysis along the progression of gastric marginal zone B‐cell lymphoma of mucosa‐associated lymphoid tissue (MALT) type
한글로보기https://www.riss.kr/link?id=O106427617
- 저자
- 발행기관
- 학술지명
- 권호사항
-
발행연도
2021년
-
작성언어
eng
-
Print ISSN
0007-1048
-
Online ISSN
1365-2141
-
등재정보
SCI;SCIE;SCOPUS
-
자료형태
학술저널
-
원정보자원
British journal of haematology
-
수록면
369-374 [※수록면이 p5 이하이면, Review, Columns, Editor's Note, Abstract 등일 경우가 있습니다.]
-
구독기관
- 전북대학교 중앙도서관
- 성균관대학교 중앙학술정보관
- 부산대학교 중앙도서관
- 전남대학교 중앙도서관
- 제주대학교 중앙도서관
- 중앙대학교 서울캠퍼스 중앙도서관
- 인천대학교 학산도서관
- 숙명여자대학교 중앙도서관
- 서강대학교 로욜라중앙도서관
- 계명대학교 동산도서관
- 충남대학교 중앙도서관
- 한양대학교 백남학술정보관
- 이화여자대학교 중앙도서관
- 고려대학교 도서관
- ⓒ COPYRIGHT THE BRITISH LIBRARY BOARD: ALL RIGHT RESERVED
-
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다국어 초록 (Multilingual Abstract)
Extra‐nodal marginal zone B‐cell lymphoma (MZBL) of mucosa‐associated lymphoid tissue is an indolent lymphoma mostly affecting the gastrointestinal tract. The lymphoma initially has small‐cell morphology (SC‐MZBL) and often arises in the background of Helicobacter pylori‐induced gastritis. In some cases, a clonal malignant progression to large‐cell morphology (LC‐MZBL) is observed. Here, we studied the DNA methylation profile of 30 gastric MZBLs along their progression. Genome‐wide DNA methylation profiling, identified 7698 significantly differentially methylated loci during gastric MZBL progression (σ/σmax ≥0·4, q ≤ 0·001). LC‐MZBL showed hypermethylation in comparison to SC‐MZBL with an enrichment of regions involved in transcriptional regulation. In conclusion, our present data show that the morphological distinction between SC‐ and LC‐MZBL is reflected by characteristic DNA methylation profiles.
Extra‐nodal marginal zone B‐cell lymphoma (MZBL) of mucosa‐associated lymphoid tissue is an indolent lymphoma mostly affecting the gastrointestinal tract. The lymphoma initially has small‐cell morphology (SC‐MZBL) and often arises in the background of Helicobacter pylori‐induced gastritis. In some cases, a clonal malignant progression to large‐cell morphology (LC‐MZBL) is observed. Here, we studied the DNA methylation profile of 30 gastric MZBLs along their progression. Genome‐wide DNA methylation profiling, identified 7698 significantly differentially methylated loci during gastric MZBL progression (σ/σmax ≥0·4, q ≤ 0·001). LC‐MZBL showed hypermethylation in comparison to SC‐MZBL with an enrichment of regions involved in transcriptional regulation. In conclusion, our present data show that the morphological distinction between SC‐ and LC‐MZBL is reflected by characteristic DNA methylation profiles.
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