급성 관동맥 증후군 환자에서 혈소판 세포질내 칼슘 이온 농도 = Platelet Cytoplasmic Ca2+ Concentration in Patients with Acute Coronary Syndromes

다국어 초록 (Multilingual Abstract)

-Abstract- Platelets aggregation on a fissured atherosclerotic plaque in the coronary artery can reduce coronary blood flow and lead o the acute coronary syndromes of unstable angina, acute myocardial infarction and ischemic sudden death. To evaluate the platelet activation in patients with unstable angina or acute myocardial infarction, we measured the resting platelet cytoplasmic Ca2+ concentration in 11 patients with the acute coronary syndromes (6 patients with unstable angina, 5 patients with acute myocardial infarction) 7 to 10 days after admissions and in 10 normal controls. After loading of a fluorescent probe, quin 2, we measured platelet cytoplasmic Ca2+ concentration with a spectrofluorometer. Platelet cytoplasmic Ca2+ concentration of patients with the acute coronary syndromes (213 ± 41 nM) was not different from that of normal controls (205 ± 38 nM). These results suggested that circulating platelets from patients with the acute coronary syndromes during recovering periods were not in an activated state.