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다국어 초록 (Multilingual Abstract)

The present study was carried out to investigate the potential adverse effects of amitraz on pregnant dams after maternal exposure during the gestational days (GD) 1 through 19 in Sprague-Dawley rats. The test chemical was administered orally to pregnant rats at dose levels of 0, 3, 10, or 30 mg/kg/ day. During the test period, clinical signs, mortality, body weights, food consumption, serum biochemistry, gross findings, organ weights and reproductive findings on GD 20 were examined. In the 30 mg/kg group, an increase in the incidence of abnormal clinical signs and death, a suppression in the body weight gain, and a decrease in the food consumption were observed. A decrease in the liver weight and increases in the kidneys, adrenal glands and heart weights were also found. Serum biochemical investigations revealed increases in the aspartate aminotransferase (AST), total bilirubin, and chloride. In addition, an increase in the fetal death and decreases in the litter size and fetal body weight were seen at caesarean section. Inthe 10 mg/kg group, an increase in the incidence of abnormal clinical signs, decreases in the food consumption and liver weight, increases in the total bilirubin and chloride, and a decrease in the fetal body weight were observed. There were no adverse effects on clinical signs, mortality, body weights, food consumption, serum biochemistry, gross findings, organ weights and reproductive findings in the 3 mg/kg group. Based on the results, it was concluded that the 19-day repeated oral dose of amitraz to pregnant rats caused increases in the clinical signs, kidneys, adrenal glands and heart weights, AST, total bilirubin and chloride and decreases in the body weight gain, food consumption and liver weight at the dose levels of above 10 mg/kg/day. Under the present experimental conditions, the no-observed-adverse-effect level (NOAEL) of amitraz was considered to be 3 mg/kg/day.

참고문헌 (Reference)

1 "개에서 진드기 살충제 amitraz의 단회피하투여 독성시험" 14 : 547-552, 2004

2 "Use of ranks in one criterion variance analysis" 614-617, 1952

3 "The usefulness of alkaline solutions for clearing the uterus and staining implantation sites in rats" 37 : 325-331, 1998

4 "The influence of amitraz on biochemical parameters in mice" 22 : 99-101, 2003

5 "The Clinical Chemistry of Laboratory Animals" Taylor & Francis, Philadelphia 1999

6 "Teratogenic effects of amitraz and paraquat on developing frog (Xenopus) embryos. Arch. Environ. Contam" 43 : 42-49, 2002

7 "Statistical Methods: Experimental Design and Scientific Inference. pp. 1-323," Oxford University Press 1-323, 1995

8 "Sprague-Dawley rats의 혈액학 및 혈액생화학치의 자료분석" 11 : 141-145, 1995

9 "Selection of the valid number of sampling units and a consideration of their combination in toxicological studies involving reproduction teratogenesis or carcinogenesis" 77-182, 1970

10 "Royal Society of Chemistry Information Systems,3rd ed" surrey : 1994-, Ltd