Epidermal nevus syndrome is the association of any type of epidermal nevus with systemic involvement, including various ocular, neurological, skeletal, cardiovascular, or urogenital developmental abnormalities. Although two reports have shown the effi...
Epidermal nevus syndrome is the association of any type of epidermal nevus with systemic involvement, including various ocular, neurological, skeletal, cardiovascular, or urogenital developmental abnormalities. Although two reports have shown the efficacy of Er:YAG lasers in the treatment, of epidermal nevi, there is no reported case of their efficacy in the treatment of epidermal nevus syndrome. A 55-year-old man had a history of multiple verrucous plaques on his entire body along Blaschko’s lines since birth. The patient had moderate mental retardation and ocular hemangiomas. Based on the clinical findings, epidermal nevus syndrome was diagnosed. He was treated using 2940 nm Er:YAG laser with a 3-5 mm spot size, pulse energy of 800-1000 mJ, fluence of 5.0-11.0 J/cm2. A significant clinical improvement was seen 2 months after one session of laser treatment. There was no relapse at the 12-month follow-up after completion of treatment. We consider that Er:YAG laser ablation is a safe, simple, effective treatment option for extensive cutaneous lesions in epidermal nevus syndrome.