<P>Two well-known appetite-regulatory peptides, leptin and cocaine-and amphetamine-regulated transcript (CART), are known to be involved in the brain rewarding pathway. However, it is not yet known how they interact in the nucleus accumbens, an ...
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https://www.riss.kr/link?id=A107430632
2017
-
SCI,SCIE,SCOPUS
학술저널
701-704(4쪽)
0
상세조회0
다운로드다국어 초록 (Multilingual Abstract)
<P>Two well-known appetite-regulatory peptides, leptin and cocaine-and amphetamine-regulated transcript (CART), are known to be involved in the brain rewarding pathway. However, it is not yet known how they interact in the nucleus accumbens, an ...
<P>Two well-known appetite-regulatory peptides, leptin and cocaine-and amphetamine-regulated transcript (CART), are known to be involved in the brain rewarding pathway. However, it is not yet known how they interact in the nucleus accumbens, an important region mediating the rewarding effects of drugs of abuse. Using the immunoassay method, we found that a microinjection of leptin into the nucleus accumbens core induces an immediate and transient increase of the CART peptide in this site, whereas these effects were inhibited by cocaine. These results expand the role of accumbal leptin to the regulation of the CART peptide and further suggest that possible interaction of these appetite-regulating peptides may be involved in cocainemediated rewarding effects. Copyright (C) 2017 Wolters Kluwer Health, Inc. All rights reserved.</P>