麻杏薏甘湯의 消炎·鎭痛·解熱作用 = Anti-inflammatory, Analgesic and Antipyretic Actiona of Ma-haeng-eui-gam-Tang

다국어 초록 (Multilingual Abstract)

The anti-inflammatory activity of water extract of Mahaengeuigam-Tang(MHEGTWE) was examined using the carrageenin and acetic acid induced edema, croton oil induced granuloma pouch, and adjuvant arthritis in rats.
In addition, the acute toxicity, analgesic and antipyretic effects of MHEGTWE were investigated by the general experimental methods In acute toxicity test in mice, MHEGTWE showed 10% mortahty at 2400 mg/kg(p.o), but it &d not showed at 1200 mg/kg(ip) significant analgesic action on the writhing syndrome induced by 0.7% acetic acid at 600 mg/kg(po) and its antipyretic activity was observed in the typhoid vaccine induced fevered rats at 300 It was also showed mg/kg(p.o).
By the oral administration of the MHEGTWE, the significant anti-inflammatory activity was observed on 1% carrageenin induced edema, and it Significantly inhibited the granuloma and exudate formation m rats In the adjuvant arthritis experiment, the MHEGTWE decreased the hind paw edema in rats for 19 days.
The levels of s-GOT, s-GPT and total cholesterol in serum did not change The results suggest that MHEGTWE has analgesic, anti-inflammatory and antipyretic action.

목차 (Table of Contents)

• 목차 = ⅰ
• ABSTRACT = ⅳ
• Ⅰ. 序論 = 1
• Ⅱ. 實驗 = 2
• 1. 實驗材料 및 實驗動物 = 2
• 1) 實驗材料 = 2
• 2) 檢液의 調製 = 2
• 3) 試藥 및 實驗器機 = 2
• 4) 實驗動物 = 2
• 2. 實驗方法 = 3
• 1) 急性毒性 實驗 = 3
• 2) 鎭痛效果 = 3
• 3) 解熱效果 = 3
• 4) Carrageenin 浮腫抑制效果 = 3
• 5) 肉芽囊 抑制效果 = 4
• 6) Adjuvant로 유발된 關節炎에 미치는 效果 = 4
• 7) 혈청중 transaminase 활성도 및 T-cholesterol 측정 = 4
• Ⅲ. 實驗結果 및考察 = 5
• 1. 急性毒性 = 5
• 2. 鎭痛效果 = 5
• 3. 解熱效果 = 7
• 4. Carrageenin 浮腫抑制效果 = 8
• 5. 肉芽囊 抑制效果 = 9
• 6. Adjuvant로 誘發된 關節炎에 미치는 效果 = 11
• 7. 혈청중 transaminase 활성도 및 T-cholesterol치에 미치는 效果 = 12
• Ⅳ. 結論 = 14
• 參考文獻 = 15