Objectives : Geopungjeseub-tang(Gufengchushi-tang) has been used in oriental medicine for many centuries as a therapeutic agent for hemiplegia caused by deficiency of qi(氣虛) and damp phlegm(濕痰). This study was performed to evaluate effects of ...
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https://www.riss.kr/link?id=A100743170
홍석 ; 전상윤 ; Hong, Seok ; Jeon, Sang-Yun
2005
Korean
KCI등재후보
학술저널
596-604(9쪽)
2
0
상세조회0
다운로드다국어 초록 (Multilingual Abstract)
Objectives : Geopungjeseub-tang(Gufengchushi-tang) has been used in oriental medicine for many centuries as a therapeutic agent for hemiplegia caused by deficiency of qi(氣虛) and damp phlegm(濕痰). This study was performed to evaluate effects of ...
Objectives : Geopungjeseub-tang(Gufengchushi-tang) has been used in oriental medicine for many centuries as a therapeutic agent for hemiplegia caused by deficiency of qi(氣虛) and damp phlegm(濕痰). This study was performed to evaluate effects of Geopungjeseub-tang extract(GJT) on hemodynamics[regional cerebral blood flow(rCBF), pial arterial diameter(PAD), mean arterial blood pressure(MABP), heart rate(HR)] in normal rats and in rats with cerebral ischemia by middle cerebral artery(MCA) occlusion. Also, effects of adrenergic ${\beta}-receptor$, cyclooxygenase on response to GJT were evaluated. Methods : Laser-doppler flowmetry(LDF) measured changes of rCBF, MABP and HR. Video microscope and width analyzer measured changes in PAD. Results : rCBF and PAD increased after treatment with GJT(10mg/kg, i.v.) during the period of cerebral reperfusion, and pretreatment with indomethacin raised rCBF and PAD increased after treatment with GJT during the same period as above. Pretreatment with propranolol decreased rCBF, but increased after GJT treatment, but raised PAD increased after GJT treatment during this period of reperfusion. Conclusion : CR caused diverse responses were observed in rCBF and PAD after treatment with GJT. ACF action is mediated by adrenergic ${\beta}-receptor$ and cyclooxygenase. Result suggest that GJT has an anti-ischemic effect through the improvement of cerebral hemodynamics and has theraputic potential for cerebral apoplexy.
참고문헌 (Reference)
1 "?㎃???이 백서의 뇌혈류개선 및 작용기전에 미치는 효과." 14 (14): 233-44, 2000
2 "?|?t???a" 켓?싱? 509-11, 2000
3 "?[???㎃???이 뇌혈류개선 및 작용기전에 미치는 영향" 15 (15): 325-31, 2001
4 "이우주의 약리학 강의(제4판)." 의학문화사 82-, 1998
5 "삼소음이 백서의 국소뇌혈류량과 혈압에 미치는 영향" 23 (23): 339-, 2002
6 "璃힛쟁 자침이 혈압과 뇌혈류역학에 미치는 영향" 16 (16): 307-19, 1999
7 "Winn HR. Reactivity of rat pial arterioles and venules to adenosine and carbon dioxide with detailed description of the closed cranial window technique in rats. J. Cereb Blood Flow Metab. 1986" 34-41,
8 "Patterson JL. Detailed description of a cranial window technique for acute and chronic experiments. Stroke. 1975" 308-17,
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1 "?㎃???이 백서의 뇌혈류개선 및 작용기전에 미치는 효과." 14 (14): 233-44, 2000
2 "?|?t???a" 켓?싱? 509-11, 2000
3 "?[???㎃???이 뇌혈류개선 및 작용기전에 미치는 영향" 15 (15): 325-31, 2001
4 "이우주의 약리학 강의(제4판)." 의학문화사 82-, 1998
5 "삼소음이 백서의 국소뇌혈류량과 혈압에 미치는 영향" 23 (23): 339-, 2002
6 "璃힛쟁 자침이 혈압과 뇌혈류역학에 미치는 영향" 16 (16): 307-19, 1999
7 "Winn HR. Reactivity of rat pial arterioles and venules to adenosine and carbon dioxide with detailed description of the closed cranial window technique in rats. J. Cereb Blood Flow Metab. 1986" 34-41,
8 "Patterson JL. Detailed description of a cranial window technique for acute and chronic experiments. Stroke. 1975" 308-17,
9 "Nathan CF. Nitric oxide a macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells. J. Exp. Med. 1989" 1543-55,
10 "Krasney J. Methylene blue inhibits hypoxic cerebral vasodilation in awake sheep. J. Appl. Physiol. 1992" 2226-32,
11 "Cummins R. Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 1989" 84-91,
12 "Balentine JD. A model of focal ischemic stroke in the rat" 738-43,
은교산(銀翹散)과 Quinolone계 항생제의 병용(倂用)이 호기성 Gram(-) 세균주(細菌株)에 대한 시험관내(試驗管內) 항균력(抗菌力)에 미치는 영향
시호(柴胡)가 뇌허혈유발 노령(老齡) 흰쥐의 해마 c-Fos 및 c-Jun 발현에 미치는 영향
백일해(百日咳) 유발균(誘發菌) Bordetella pertussis에 대한 호장근(虎杖根)의 생육(生育) 억제(抑制) 효과(效果)
과루인약침(瓜蔞仁藥鍼)이 Ovalbumin-induced Asthma Mouse Model에 미치는 영향(影響)
학술지 이력
연월일 | 이력구분 | 이력상세 | 등재구분 |
---|---|---|---|
2022 | 평가예정 | 재인증평가 신청대상 (재인증) | |
2019-01-01 | 평가 | 등재학술지 유지 (계속평가) | |
2016-01-01 | 평가 | 등재학술지 선정 (계속평가) | |
2015-12-01 | 평가 | 등재후보로 하락 (기타) | |
2011-01-01 | 평가 | 등재학술지 유지 (등재유지) | |
2009-01-01 | 평가 | 등재학술지 유지 (등재유지) | |
2006-02-09 | 학술지명변경 | 외국어명 : THE KOREAN SOCIETY FOR ORIENTAL INTERNAL MEDICINE -> The Journal of Korean Oriental Internal Medicine | |
2006-01-01 | 평가 | 등재학술지 선정 (등재후보2차) | |
2005-01-01 | 평가 | 등재후보 1차 PASS (등재후보1차) | |
2003-01-01 | 평가 | 등재후보학술지 선정 (신규평가) |
학술지 인용정보
기준연도 | WOS-KCI 통합IF(2년) | KCIF(2년) | KCIF(3년) |
---|---|---|---|
2016 | 0.67 | 0.67 | 0.61 |
KCIF(4년) | KCIF(5년) | 중심성지수(3년) | 즉시성지수 |
0.56 | 0.5 | 0.653 | 0.03 |