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      KCI등재 SCIE SCOPUS

      Anti-inflammatory Effects of Eriodictyol in Lipopolysaccharidestimulated Raw 264.7 Murine Macrophages

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      https://www.riss.kr/link?id=A104667531

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      다국어 초록 (Multilingual Abstract)

      Flavonoids have biological activities including anti-allergic, anti-inflammatory, antimicrobial and anticancer activities shown from in vitro studies. Of these biological activities, the antiinflammatory capacity of flavonoids has long been emphasized...

      Flavonoids have biological activities including anti-allergic, anti-inflammatory, antimicrobial and anticancer activities shown from in vitro studies. Of these biological activities, the antiinflammatory capacity of flavonoids has long been emphasized in Chinese medicine. In this study, I investigated that what flavonoid can be applied to the suppression of lipopolysaccharide (LPS)-induced inflammatory responses in macrophages among the four similar structure flavonoids. Eriodictyol was found to reduce nitric oxide (NO) production from LPS-stimulated Raw 264.7 cells in non-cytotoxic concentrations. Moreover, eriodictyol strongly suppressed the phagocytic activity of activated macrophages. Pre-treatment of Raw 264.7 cells with eriodictyol reduced the expression of mRNA and the secretion of pro-inflammatory cytokines. These inhibitory effects were found to be caused by blockage of nuclear factor kappa-light-chainenhancer of activated B cells (NF-κB) activation and phosphorylation of p38 mitogen-activated protein kinase (MAPK), extracellular signal-regulated kinases 1 and 2 (ERK1/2) and c-Jun Nterminal kinase (JNK).

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      참고문헌 (Reference)

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      2 LaDuca, J. R, "Targeting tumor necrosis factor alpha. New drugs used to modulate inflammatory diseases" 19 : 617-635, 2001

      3 Lee, J. K., "Suppression of the TRIF-dependent signaling pathway of Toll-like receptors by luteolin" 77 : 1391-1400, 2009

      4 Liang, Y. C., "Suppression of inducible cyclooxygenase and inducible nitric oxide synthase by apigenin and related flavonoids in mouse macrophages" 20 : 1945-1952, 1999

      5 Brennan, F. M., "Role of proinflammatory cytokines in rheumatoid arthritis" 20 : 133-147, 1998

      6 Ignarro, L. J., "Regulation of cytosolic guanylyl cyclase by porphyrins and metalloporphyrins" 26 : 35-65, 1994

      7 Bai, X. C., "Reactive oxygen species stimulates receptor activator of NFkappaB ligand expression in osteoblast" 280 : 17497-17506, 2005

      8 Amirzargar, A., "Profile of cytokine gene polymorphisms in Iranian multiple sclerosis patients" 13 : 253-255, 2007

      9 Lawrence, T., "Possible new role for NF-kappaB in the resolution of inflammation" 7 : 1291-1297, 2001

      10 Beckman, J. S., "Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly" 271 : C1424-C1437, 1996

      1 Kean, R. B., "The peroxynitrite scavenger uric acid prevents inflammatory cell invasion into the central nervous system in experimental allergic encephalomyelitis through maintenance of blood-central nervous system barrier integrity" 165 : 6511-6518, 2000

      2 LaDuca, J. R, "Targeting tumor necrosis factor alpha. New drugs used to modulate inflammatory diseases" 19 : 617-635, 2001

      3 Lee, J. K., "Suppression of the TRIF-dependent signaling pathway of Toll-like receptors by luteolin" 77 : 1391-1400, 2009

      4 Liang, Y. C., "Suppression of inducible cyclooxygenase and inducible nitric oxide synthase by apigenin and related flavonoids in mouse macrophages" 20 : 1945-1952, 1999

      5 Brennan, F. M., "Role of proinflammatory cytokines in rheumatoid arthritis" 20 : 133-147, 1998

      6 Ignarro, L. J., "Regulation of cytosolic guanylyl cyclase by porphyrins and metalloporphyrins" 26 : 35-65, 1994

      7 Bai, X. C., "Reactive oxygen species stimulates receptor activator of NFkappaB ligand expression in osteoblast" 280 : 17497-17506, 2005

      8 Amirzargar, A., "Profile of cytokine gene polymorphisms in Iranian multiple sclerosis patients" 13 : 253-255, 2007

      9 Lawrence, T., "Possible new role for NF-kappaB in the resolution of inflammation" 7 : 1291-1297, 2001

      10 Beckman, J. S., "Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly" 271 : C1424-C1437, 1996

      11 Lowenstein, C. J., "Nitric oxide inhibits viral replication in murine myocarditis" 97 : 1837-1843, 1996

      12 Stichtenoth, D. O., "Nitric oxide and inflammatory joint diseases" 37 : 246-257, 1998

      13 Ialenti, A., "Modulation of acute inflammation by endogenous nitric oxide" 211 : 177-182, 1992

      14 Johnson, G. L., "Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases" 298 : 1911-1912, 2002

      15 Kinne, R. W., "Macrophages in rheumatoid arthritis" 2 : 189-202, 2000

      16 Xagorari, A., "Luteolin inhibits an endotoxin-stimulated phosphorylation cascade and proinflammatory cytokine production in macrophages" 296 : 181-187, 2001

      17 Ito, H., "Isoflavonoids from Belamcanda chinensis" 49 : 1229-1231, 2001

      18 Kishimoto, T., "Interleukin-6 family of cytokines and gp130" 86 : 1243-1254, 1995

      19 Narumi, S., "Interferon gamma and interleukin 2 synergize to induce selective monokine expression in murine peritoneal macrophages" 265 : 7036-7041, 1990

      20 Sang Yeol Lee, "Inhibitory effects of honokiol on LPS and PMA-induced cellular responses of macrophages and monocytes" 한국생화학분자생물학회 42 (42): 574-579, 2009

      21 Comalada, M., "Inhibition of pro-inflammatory markers in primary bone marrowderived mouse macrophages by naturally occurring flavonoids: analysis of the structure-activity relationship" 72 : 1010-1021, 2006

      22 Kim, S, H., "Inhibition of p38 and ERK MAP kinases blocks endotoxin-induced nitric oxide production and differentially modulates cytokine expression" ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD 49 (49): 433-439, 2004

      23 Stuehr, D. J., "Induction of nitrite/nitrate synthesis in murine macrophages by BCG infection, lymphokines, or interferon-gamma" 139 : 518-525, 1987

      24 Huang, D. W., "Identification of compounds in adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) seed hull extracts that inhibit lipopolysaccharide-induced inflammation in Raw 264.7 macrophages" 57 : 10651-10657, 2009

      25 Xing, Z., "IL-6 is an antiinflammatory cytokine required for controlling local or systemic acute inflammatory responses" 101 : 311-320, 1998

      26 Bian, Z. M., "Human RPE-monocyte co-culture induces chemokine gene expression through activation of MAPK and NIK cascade" 76 : 573-583, 2003

      27 Choo, Q. Y., "Histone deacetylase inhibitors: new hope for rheumatoid arthritis" 14 : 803-820, 2008

      28 Havsteen B., "Flavonoids, a class of natural products of high pharmacological potency" 32 : 1141-1148, 1983

      29 Cheon, B. S., "Effects of prenylated flavonoids and biflavonoids on lipopolysaccharide-induced nitric oxide production from the mouse macrophage cell line Raw 264.7" 66 : 596-600, 2000

      30 Kim, H. K., "Effects of naturally occurring flavonoids on nitric oxide production in the macrophage cell line Raw 264.7 and their structure-activity relationships" 58 : 759-765, 1999

      31 Middleton, E. Jr., "Effect of plant flavonoids on immune and inflammatory cell function" 439 : 175-182, 1998

      32 Morgan, M. M., "Dissociation of hyperalgesia from fever following intracerebroventricular administration of interleukin-1beta in the rat" 1022 : 96-100, 2004

      33 Butler, D. M., "DBA/1 mice expressing the human TNF-alpha transgene develop a severe, erosive arthritis: characterization of the cytokine cascade and cellular composition" 159 : 2867-2876, 1997

      34 Duval, D. L., "Characterization of hepatic nitric oxide synthase: identification as the cytokine-inducible form primarily regulated by oxidants" 50 : 277-284, 1996

      35 Dinarello, C. A., "Biologic basis for interleukin-1 in disease" 87 : 2095-2147, 1996

      36 Huk, I., "Bioflavonoid quercetin scavenges superoxide and increases nitric oxide concentration in ischaemia-reperfusion injury: an experimental study" 85 : 1080-1085, 1998

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      학술지 이력
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      2023 평가예정 해외DB학술지평가 신청대상 (해외등재 학술지 평가)
      2020-01-01 평가 등재학술지 유지 (해외등재 학술지 평가) KCI등재
      2010-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2008-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2006-01-01 평가 등재학술지 유지 (등재유지) KCI등재
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      1998-07-01 평가 등재후보학술지 선정 (신규평가) KCI등재후보
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      학술지 인용정보
      기준연도 WOS-KCI 통합IF(2년) KCIF(2년) KCIF(3년)
      2016 1.96 0.2 1.44
      KCIF(4년) KCIF(5년) 중심성지수(3년) 즉시성지수
      1.07 0.87 0.439 0.05
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