조기 성문암에서 방사선치료 반응 예측 인자로서 bcl-2, c-myc, EGFR의 면역조직화학적 연구 = Immunohistochemical Study on bcl-2, c-myc, EGFR as Predictable Factor for Radiosensitivity in Early Glottic Cancer

다국어 초록 (Multilingual Abstract)

Background and Objectives：of radiotherapy is the preservation of good voice quality after treatment but the main problem is increased complications in the salvage surgery when local control fails. So, it is important to predict the success of radiotherapy. The purpose of this study is to find predictable factors of the radiosensitivity in the early glotic cancer. Materials and Method：Imunohistochemical staining was performed on the parafin sections of the biopsy specimens of 57 patients with early glottic cancer who had undertaken the anti-bcl-2 monoclonal antibody, the anti-c-myc monoclonal antibody, and the anti-EGFR monoclonal antibodies. The relation betwen the local control outcome after radiotherapy and the result of imunostaining was analyzed by the chi-square and the Fishers exact test. Results：Positive expresion of bcl-2 was 21.1% in the local controlled group and 12.3% in the uncontrolled group. There was no statistical significance between two groups. The expresion rate of c-myc was statisticaly higher in the controlled group (36.8%) than in the uncontrolled group (7.0%) (p=0.025). Expresion of EGFR was 57.9% in the controlled group and 22.5% in the uncontolled group. However, there was no statistical significance betwen two groups. Conclusion：The relation betwen the positive c-myc expression and the radiosensitivity sugests that c-myc might be a predictable factor of the radiosensitivity in early glottic cancer. (Korean J Otolaryngol 2003 ;46 :134-8)