鼻粘膜 病巢의 形質細胞에 對한 免疫組織化學的 硏究 = An Immunohistochemical Study of Plasma Cells in Human Allergic and Non-allergic Rhinitis

다국어 초록 (Multilingual Abstract)

Rhinitis is one of common diseases affecting human and can be divided into two major types, allergic and nonallergic. Allergic rhinitis is diagnosed by clinical histories correlating with skin tests, gross findings of nasal mucosa, and elevated serum Ig E. The eosinophill a, which is highly characteristic but not confirmative of allergic rhinitis, was invariably noted in the clinical entity such as nasal polyposis, perennial nonallergic rhinitis, and aspirin intolerance. The author had performed an experimental study using rabbit antithuman Ig G. Ig M, and Ig A on the tissue sections of nasal mucosa in order to find differences between allergic and nonallergic rhinitis, and also counted the numbers of tissue mast cells in the lesion.
The results obtained are as follows;
1. In nonallergic rhinitis, all the cases examined showed plasma cells which react to antihuman Ig G and Ig A especially in the edematous connective tissue and periglandular areas.
2. In allergic rhinitis, most plasma cells in the lesion reacted with Ig A antibody.
3. Plasma cells which react to the antihuman Ig M antibody were found less than half in cases of both nonallergic and allergic rhinitis.
4. The numbers of tissue mast cells were significantly increased in the cases of allergic rhinitis than those of nonallergic rhinitis.
With the above results, it seems to be possible to differentiate allergic rhinitis from nonallergic rhinitis by scarcity of plasma cells which react antihuman Ig G antibody and increase in numbers of tissue mast cells.