흡입독성 연구를 위한 2730ppm 납 네뷸라이징 용액에서 발생된 에어로졸의 입경분석 = Particle Size Analysis of Lead Aerosol with the use of 2730ppm Lead Nebulizing Solution for Inhalation Toxicology Study

다국어 초록 (Multilingual Abstract)

Ultrasonic nebulizer with the application of new engineering methodology and the design of electronic circuit was made for lead inhalation toxicology study and 2730ppm lead nebulizing solution was used to generate lead aerosol. After modification of source and inlet temperatures, the results of particle size analysis for lead aerosol were as following. The highest particle counting for source temperature 20˚c was 39933.66 in inlet temperature 100˚C and particle diameter 0.75㎛. The highest particle counting for source temperature 50˚C was 39992.71 in inlet temperature 250˚C and particle diameter 0.75㎛. The highest particle counting for source temperature 70˚C was 37569.55 in inlet temperature 50˚C and particle diameter 0.75㎛. The ranges of geometric mean diameter(GMD) were 0.754-0.784㎛ for source temperature 20˚C, 0.758-0.852㎛ for source temperature 50˚C, and 0.869-1.060㎛ for source temperature 70˚C. The smallest GMD was 0.754㎛ in source temperature 20˚C and inlet temperature 20˚C, and the largest GMD was 1.060㎛ in source temperature 70˚C and inlet temperature 250˚C. The ranges of geometric standard deviation(GSD) were 1.730-1.782 for source temperature 20˚c, 1.734-1.894 for source temperature 50˚C, and 1.921-2.148 for source temperature 70˚C. The lowest GSD was 1.730 in source temperature 20˚c and inlet temperature 20˚C, and the highest GSD was 2.148 in source temperature 70˚C and inlet temperature 250˚C. Lead aerosol generated in this study was polydisperse. The ranges of mass median diameter(MMD) were 1.856-2.133㎛ for source temperature 20˚C, 1.877-2.894㎛ for source temperature 50˚C, and 3.120-6.1091m for source temperature 70˚C. The smallest MMD was 1.856㎛ in source temperature 20˚C and inlet temperature 20˚C, and the largest MMD was 6.109㎛ in source temperature 70˚C and inlet temperature 250˚C. Slight increases for GMD, GSD, and MMD values were observed with same source temperature and increase of inlet temperature. MMD for inhalation toxicology testing in EPA guidance is less than 4㎛. In this study, source temperature 20˚C and 50˚C with inlet temperature from 20˚C to 250˚C were conformed to the EPA guidance, but inlet temperature 20˚C and 50˚C for source temperature 70˚C were conformed EPA guidance. MMD for inhalation toxicology testing in OECD and EU is less than 3,um. In this study, source temperature 20˚C and 50˚C with inlet temperature from 20˚C to 250˚C were conformed to the EPA guidance, but none for source temperature 70˚C.