Exposure to genistein does not adversely affect the reproductive system in adult male mice adapted to a soy-based commercial diet

다국어 초록 (Multilingual Abstract)

Genistein, a soybean-originated isoflavone, is widely consumed by humans for putative beneficial health effects but its estrogenic activity may affect adversely the development of male reproductive system. Five-week-oldICR mice were purchased and fed with a soybean-based Purina Chow diet until 6 months of age. The animals were xposed by gavage to genistein (2.5 mg/kg/day) or 17β-estradiol (7.5 μg/kg/day) for five weeks. Corn oil was used for the negative control. The animals were fed the caseinbasedAIN-76A diet throughout the experimental periods. There were no significant differences in body and organ weights of mice among experimental groups. Nosignificant differences in sperm counts and sperm motile characteristics were found between the control and the genistein groups. Treatment of 17β-estradiol caused asignificant decrease in epididymal sperm counts compared to the control (p < 0.05). The level of phospholipid hydroxide glutathione peroxidase in the epididymis ofmice exposed to genistein was significantly higher than that of the control mice (p < 0.05). 17β-estradiol treatment caused a reduction of germ cells in the testis andhyperplasia of mucosal fold region in the prostate of mice. Genistein treatment did not cause any lesion in the testis,epididymis, and prostate. These results suggest thatdietary uptake of genistein at adult stage of life may not affect male reproductive system and functions.

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