Physiological Characteristics and Anti-obesity Effect of Lactobacillus plantarum Q180 Isolated from Feces

다국어 초록 (Multilingual Abstract)

Obesity is strongly associated with several metabolic and chronic diseases and has become a major public health problemof worldwide concern. This study aimed to investigate the physiological characteristics and anti-obesity effects of Lactoba-cillus plantarum Q180. Lactobacillus plantarum Q180 was isolated from the faces of healthy adults and found to have alipase inhibitory activity of 83.61±2.32% and inhibited adipocyte differentiation of 3T3-L1 cells (14.63±1.37%) at a con-centration of 100 µg/mL. The strain was investigated for its physiological characteristics. The optimum growth temperatureof L. plantarum Q180 was 37oC. Lactobacillus plantarum Q180 showed higher sensitivity to novobiocin in a comparisonof fifteen different antibiotics and showed the highest resistance to rifampicin, polymyxin B and vancomycin. The strainshowed higher β-galactosidase and N-acetyl-β-glucosaminidase activities. It also did not produce carcinogenic enzymessuch as β-glucuronidase. The survival rate of L. plantarum Q180 in MRS broth containing 0.3% bile was 97.8%. Moreover,the strain showed a 97.2% survival rate after incubation for 3 h in pH 2.0. Lactobacillus plantarum Q180 was displayedresistance to Escherichia coli, Salmonella Typhimurium and Staphylococcus aureus with rates of 55.6%, 38.0% and 47.6%,respectively. These results demonstrate that L. plantarum Q180 has potential as a probiotic with anti-obesity effects.

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