Shade Flask 법을 이용한 1-Octanol/Water 분배계수 측정 = Determination of 1-Octanol/Water Partition Coefficients by Using Shake Flask Method

다국어 초록 (Multilingual Abstract)

The 1-octanol/water partition coefficient(K_(ow)) is used to estimate the chemical`s fate and the behavior of chemicals against the organization. We want to determine the K_(ow) by using shake flask(SF) method. Firstly we established the requiring time for preparing of saturated solution and for partitioning equilibrium in the SF method with tert-butanol. The accuracy and reproducibility of this SF method was reliable since the average deviation was less than 5 % between measured K_(ow) values of alcohols(C₁-C_7) and the reported values. The K_(ow) for some chlorinated and aromatic compounds were measured. The K_(ow) of these organic chemicals were linearly proportional to their molar volumes and the relationship of K_(ow) and water solubilities can be expressed by a first order linear equation.