Introduction: Extracorporeal membrane oxygenation (ECMO) is being used for management of various cardiorespiratory conditions. The aim of this study was to develop and prove the efficacy and safety of new ECMO system in vivo porcine model.
Methods: U...
Introduction: Extracorporeal membrane oxygenation (ECMO) is being used for management of various cardiorespiratory conditions. The aim of this study was to develop and prove the efficacy and safety of new ECMO system in vivo porcine model.
Methods: Under general anesthesia, the experimental pig was undergoing mechanical ventilation with protective ventilation (volume control mode, tidal volume: 6ml/kg, Positive end expiratory pressure(PEEP) :5mmHg, Respiratory rate(RR) :10/min, I:E ratio :1:2, FIO2 :0.21) and femoral cannulation for new ECMO system using the single-site double lumen catheter. Except membrane oxygenator, whole device was newly developed including centrifugal pump and control unit with multi-functioned sensors. We monitored cardiovascular and respiratory status and checked metabolic parameters from arterial blood samples periodically for evaluation of the gas exchange, hemolysis and coagulation parameters. ACT was checked for heparinization. The pig was followed up to 12 hours.
Results: The pig showed cardiovascular and hemodynamic stability for 12 hours without bleeding or clotting complications showing stable oxygenation and carbon dioxide removal (Figure 1).
Conclusions: We established new ECMO system proving safety and efficacy with adequate oxygenation and carbon dioxide removal in a preclinical in vivo porcine model.