최근의 연구결과를 통해서 중추 신경계와 위장관은 장-뇌 축을 따라서 양방향의 상호작용이 일어나고 있다는 것이 분명해지고 있다. 전임상 연구로부터 장내 마이크로비오타가 다양한 생리...
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https://www.riss.kr/link?id=A105815192
2018
Korean
KCI등재
학술저널
1386-1395(10쪽)
1
0
상세조회0
다운로드국문 초록 (Abstract)
최근의 연구결과를 통해서 중추 신경계와 위장관은 장-뇌 축을 따라서 양방향의 상호작용이 일어나고 있다는 것이 분명해지고 있다. 전임상 연구로부터 장내 마이크로비오타가 다양한 생리...
최근의 연구결과를 통해서 중추 신경계와 위장관은 장-뇌 축을 따라서 양방향의 상호작용이 일어나고 있다는 것이 분명해지고 있다. 전임상 연구로부터 장내 마이크로비오타가 다양한 생리적 기능을 통해서 중추 신경계의 기능을 조절할 수 있음이 밝혀지고 있다. 폴리페놀 화합물은 과일, 채소, 차, 커피, 와인과 같은 식품에 존재하는 식물 유래의 물질로, 항산화, 항염증, 항균, 면역 조절, 항암, 혈관 확장 및 프리바이오틱스와 유사한 효과를 보유하고 있어 식이를 통해 섭취할 경우 건강에 직접적인 효과를 나타낸다. 최근 들어 폴리페놀 화합물이 인지 기능뿐만 아니라 산화적 스트레스 및 염증성 손상에 대해 작용하는 신경 보호에 유익한 효과를 줄 수 있다는 증거가 보고되고 있다. 본 총설에서는 신경 세포 신호 전달 경로의 자극, 신경 염증, 혈관 기능 및 장내 마이크로비옴과의 상호작용에 따른 폴리페놀 화합물의 신경 보호 효과와 관련된 작용 메커니즘에 대한 일반적인 개요를 제시한다. 폴리페놀 화합물의 대사 산물은 혈액-뇌 장벽을 가로 지르는 신경 전달 물질을 이용하고 뇌 혈관 시스템을 조절하여 작용하거나, 간접적으로 장내 마이크로비오타에 작용한다. 또한, 폴리페놀 화합물은 노화 관련 인지 기능 저하 및 신경 퇴행과 같은 신경계 질환을 다양한 생리 기능을 통해 효과적으로 관리할수 있다는 사실이 제시되고 있다. 폴리페놀 화합물은 신경 염증을 감소시키고 기억과 인지 기능을 향상 시키며 장내 마이크로비오타를 조절하는 능력을 지니고 있기 때문에 신경계 질환의 예방 및 치료에 있어 잠재적인 기능성 식품으로 주목 받을 것으로 기대된다.
다국어 초록 (Multilingual Abstract)
Over recent years, it has become evident that the central nervous system bidirectionally interacts with the gastrointestinal tract along the gut-brain axis. A series of preclinical studies indicate that the gut microbiota can modulate central nervous ...
Over recent years, it has become evident that the central nervous system bidirectionally interacts with the gastrointestinal tract along the gut-brain axis. A series of preclinical studies indicate that the gut microbiota can modulate central nervous system function through a multitude of physiological functions. Polyphenols are ubiquitous plant chemicals included in foods such as fruits, vegetables, tea, coffee and wine, and their consumption is directly responsible for beneficial health effects due to antioxidant, anti-inflammatory, antimicrobial, immunomodulatory, anticancer, vasodilating, and prebiotic-like effects. There is increasing evidence that dietary polyphenol can contribute to beneficial effects in neuronal protection acting against oxidative stress and inflammatory injury as well as in cognitive functions. In this paper, we overview the neuroprotective role of dietary polyphenols especially focusing on the neuroinflammation and neurovascular function by interaction with the gut microbiome. Polyphenol metabolites could directly act as neurotransmitters crossing the blood-brain barrier and modulating the cerebrovascular system or indirectly modulating gut microbiota. In addition, evidence suggests that dietary polyphenols are effective in preventing and managing neurological disorders, such as age-related cognitive decline and neurodegeneration, through a multitude of physiological functions. Dietary polyphenols are increasingly envisaged as a potential nutraceuticals in the prevention and treatment of neurological disorders, because they possess the ability to reduce neuroinflammation, to improve memory and cognitive function and to modulate the gut microbiota.
참고문헌 (Reference)
1 윤진아, "프로바이오틱스 중 유산균 및 관련 효모의 기능에 관한 연구 고찰" 한국식품영양학회 30 (30): 395-404, 2017
2 Breteler, M. M., "Vascular risk factors for Alzheimer’s disease: an epidemiologic perspective" 21 : 153-160, 2000
3 Pasinetti, G. M., "The role of the gut microbiota in the metabolism of polyphenols as characterized by gnotobiotic mice" 63 : 409-421, 2018
4 Dias, G. P., "The role of dietary polyphenols on adult hippocampal neurogenesis: molecular mechanisms and behavioural effects on depression and anxiety" 2012 : 2012
5 Farzaei, M. H., "The role of dietary polyphenols in the management of inflammatory bowel disease" 16 : 196-210, 2015
6 Montiel-Castro, A. J., "The microbiota- gut-brain axis: neurobehavioral correlates, health and sociality" 7 : 70-, 2013
7 Rendeiro, C., "The mechanisms of action of flavonoids in the brain: direct versus indirect effects" 89 : 126-139, 2015
8 Hattori, M., "The human intestinal microbiome: a new frontier of human biology" 16 : 1-12, 2009
9 Kessler, R. C., "The epidemiology of major depressive disorder: results from the national comorbidity survey replication (ncs-r)" 289 : 3095-3105, 2003
10 Xu, Y., "The effects of curcumin on depressive- like behaviors in mice" 518 : 40-46, 2005
1 윤진아, "프로바이오틱스 중 유산균 및 관련 효모의 기능에 관한 연구 고찰" 한국식품영양학회 30 (30): 395-404, 2017
2 Breteler, M. M., "Vascular risk factors for Alzheimer’s disease: an epidemiologic perspective" 21 : 153-160, 2000
3 Pasinetti, G. M., "The role of the gut microbiota in the metabolism of polyphenols as characterized by gnotobiotic mice" 63 : 409-421, 2018
4 Dias, G. P., "The role of dietary polyphenols on adult hippocampal neurogenesis: molecular mechanisms and behavioural effects on depression and anxiety" 2012 : 2012
5 Farzaei, M. H., "The role of dietary polyphenols in the management of inflammatory bowel disease" 16 : 196-210, 2015
6 Montiel-Castro, A. J., "The microbiota- gut-brain axis: neurobehavioral correlates, health and sociality" 7 : 70-, 2013
7 Rendeiro, C., "The mechanisms of action of flavonoids in the brain: direct versus indirect effects" 89 : 126-139, 2015
8 Hattori, M., "The human intestinal microbiome: a new frontier of human biology" 16 : 1-12, 2009
9 Kessler, R. C., "The epidemiology of major depressive disorder: results from the national comorbidity survey replication (ncs-r)" 289 : 3095-3105, 2003
10 Xu, Y., "The effects of curcumin on depressive- like behaviors in mice" 518 : 40-46, 2005
11 Lamport, D. J., "The effect of lavanol-rich cocoa on cerebral perfusion in healthy older adults during conscious resting state: a placebo controlled, crossover, acute trial" 232 : 3227-3234, 2015
12 Tully, T., "Targeting the CREB pathway for memory enhancers" 2 : 267-277, 2003
13 Mirescu, C., "Stress and adult neurogenesis" 16 : 233-238, 2006
14 Impey, S., "Stimulation of cAMP response element (CRE)-mediated transcription during contextual learning" 1 : 595-601, 1998
15 Wang, D., "Role of intestinal microbiota in the generation of polyphenol-derived phenolic acid mediated attenuation of Alzheimer’s disease beta-amyloid oligomerization" 59 : 1025-1040, 2015
16 Moussa, C., "Resveratrol regulates neuro-inflammation and induces adaptive immunity in Alzheimer's disease" 14 : 1-10, 2017
17 Poulose, S. M., "Restoration of stressor-induced calcium dysregulation and autophagy inhibition by polyphenol-rich açaí (Euterpe spp.) fruit pulp extracts in rodent brain cells in vitro" 30 : 853-862, 2014
18 Casini, M. L., "Psychological assessment of the effects of treatment with phytoestrogens on postmenopausal women: a randomized, double-blind, crossover, placebo- controlled study" 85 : 972-978, 2006
19 Dinan, T. G., "Psychobiotics: a novel class of psychotropic" 74 : 720-726, 2013
20 Lilly, D. M., "Probiotics: growth-promoting factors produced by microorganisms" 147 : 747-748, 1965
21 Kim, Y. H., "Probiotics, prebiotics, synbiotics and human health" 23 : 17-22, 2016
22 Khurana, S., "Polyphenols: benefits to the cardiovascular system in health and in aging" 5 : 3779-3827, 2013
23 Filosa, S., "Polyphenols-gut microbiota interplay and brain neuromodulation" 13 : 2055-2059, 2018
24 Martin, K. R., "Polyphenols as dietary supplements: A double-edged sword" Suppl. 2 : 1-12, 2010
25 Kennedy, D. O., "Polyphenols and the human Brain: plant “secondary metabolite” ecologic roles and endogenous signaling functions drive benefits" 5 : 515-533, 2014
26 Arts, I. C. W., "Polyphenols and disease risk in epidemiologic studies" 81 : 317-325, 2005
27 Biasi, F., "Polyphenol supplementation as a complementary medicinal approach to treating inflammatory bowel disease" 18 : 4851-4865, 2011
28 Sorond, F. A., "Neurovascular coupling, cerebral white matter integrity, and response to cocoa in older people" 81 : 904-909, 2013
29 Spencer, J. P., "Neuroinflammation: modulation by flavonoids and mechanisms of action" 33 : 83-97, 2012
30 Agostinho, P., "Neuroinflammation, oxidative stress and the pathogenesis of Alzheimer’s disease" 16 : 2766-2778, 2010
31 Cryan, J. F., "Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour" 13 : 701-712, 2012
32 Westfall, S., "Microbiome, probiotics and neurodegenerative diseases: deciphering the gut brain axis" 74 : 3769-3787, 2017
33 Aura, A. M., "Microbial metabolism of dietary phenolic compounds in the colon" 7 : 407-429, 2008
34 Ley, R. E., "Microbial ecology: human gut microbes associated with obesity" 444 : 1022-1023, 2006
35 Bowey, E., "Metabolism of isoflavones and lignans by the gut microflora: a study in germ-free and human flora associated rats" 41 : 631-636, 2003
36 Jankord, R., "Limbic regulation of hypothalamo-pituitary-adrenocortical function during acute and chronic stress" 1148 : 64-73, 2008
37 Harris, K., "Is the gut microbiota a new factor contributing to obesity and its metabolic disorders?" 2012 : 2012
38 Calder, P. C., "Inflammatory disease processes and interactions with nutrition" 101 : S1-S45, 2009
39 Aura, A. M., "In vitro metabolism of anthocyanins by human gut microflora" 44 : 133-142, 2005
40 Pipingas, A., "Improved cognitive performance after dietary supplementation with a pinus radiata bark extract formulation" 22 : 1168-1174, 2008
41 Flanagan, E., "Impact of flavonoids on cellular and molecular mechanisms underlying age-related cognitive decline and neurodegeneration" 7 : 49-57, 2018
42 Bäckhed, F., "Host-bacterial mutualism in the human intestine" 307 : 1915-1920, 2005
43 Rastmanesh, R., "High polyphenol, low probiotic diet for weight loss because of intestinal microbiota interaction" 189 : 1-8, 2011
44 Sathyapalan, T., "High cocoa polyphenol rich chocolate may reduce the burden of the symptoms in chronic fatigue syndrome" 9 : 55-, 2010
45 Wang, H. X., "Gut microbiota-brain axis" 129 : 2373-2380, 2016
46 Marques, C., "Gut microbiota modulation accounts for the neuroprotective properties of anthocyanins" 27 : 11341-, 2018
47 Mayer, E. A., "Gut microbes and the brain: paradigm shift in neuroscience" 34 : 15490-15496, 2014
48 FAO, "Guidelines for the evaluation of probiotics in food. Report of a joint FAO/WHO working group on drafting guidelines for the evaluation of probiotics in food" 2002
49 Zhu, W. L., "Green tea polyphenols produce antidepressant-like effects in adult mice" 65 : 74-80, 2012
50 Frank, D. N., "Gastrointestinal micro biology enters the metagenomics era" 24 : 4-10, 2008
51 Mrduljaš, N., "Functional Food-Improve Health through Adequate Food" IntechOpen 23-41, 2017
52 Jeffrey B. Blumberg, "Flavonols, Flavones, Flavanones, and Human Health: Epidemiological Evidence" 한국식품영양과학회 8 (8): 281-290, 2005
53 Spencer, J. P., "Flavonoids: modulators of brain function?" 99 : ES60-ES77, 2008
54 Williams, R. J., "Flavonoids: antioxidants or signalling molecules?" 36 : 838-849, 2004
55 Williams, R. J., "Flavonoids, cognition, and dementia: actions, mechanisms, and potential therapeutic utility for alzheimer disease" 52 : 35-45, 2012
56 Schroeter, H., "Flavonoids protect neurons from oxidized low-density-lipoprotein-induced apoptosis involving c-Jun N-terminal kinase (JNK), c-Jun and caspase-3" 358 : 547-557, 2001
57 García-Lafuente, A., "Flavonoids as anti-inflammatory agents: implications in cancer and cardiovascular disease" 58 : 537-552, 2009
58 Spencer, J. P., "Flavonoids and brain health: multiple effects underpinned by common mechanisms" 4 : 243-250, 2009
59 di Gesso, J. L., "Flavonoid metabolites reduce tumor necrosis factor-α secretion to a greater extent than their precursor compounds in human THP-1 monocytes" 59 : 1143-1154, 2015
60 Sandhu, K. V., "Feeding the microbiota- gut-brain axis: Diet, microbiome, and neuropsychiatry" 179 : 223-244, 2017
61 Brickman, A. M., "Enhancing dentate gyrus function with dietary flavanols improves cognition in older adults" 17 : 1798-1803, 2014
62 Witte, A. V., "Effects of resveratrol on memory performance, hippocampal functional connectivity, and glucose metabolism in healthy older adults" 34 : 7862-7870, 2014
63 Vauzour, D., "Effect of flavonoids on learning, memory and neurocognitive performance: relevance and potential implications for Alzheimer’s disease pathophysiology" 94 : 1042-1056, 2014
64 Peluso, I., "Effect of flavonoids on circulating levels of TNF-α and IL-6 in humans: a systematic review and metaanalysis" 57 : 784-801, 2013
65 Frank-Cannon, T. C., "Does neuroinflammation fan the flame in neurodegenerative diseases" 4 : 47-, 2009
66 Eckburg, P. B., "Diversity of the human intestinal microbial flora" 308 : 1635-1638, 2005
67 Serra, D., "Dietary polyphenols: a novel strategy to modulate microbiota-gut- brain axis" 78 : 224-233, 2018
68 Vauzour, D., "Dietary polyphenols as modulators of brain functions: biological actions and molecular mechanisms underpinning their beneficial effects" 2012 : 2012
69 Rendeiro, C., "Dietary levels of pure flavonoids improve spatial memory performance and increase hippocampal brain-derived neurotrophic factor" 8 : e63535-, 2013
70 Del Rio, D., "Dietary (poly) phenolics in human health: Structures, bioavailability, and evidence of protective effects against chronic diseases" 18 : 1818-1892, 2013
71 Puupponen-Pimiä, R., "Development of functional ingredients for gut health" 13 : 3-11, 2002
72 O'Brien, S. M., "Cytokines: abnormalities in major depression and implications for pharmacological treatment" 19 : 397-403, 2004
73 Dantzer, R., "Cytokine, sickness behavior, and depression" 29 : 247-264, 2009
74 DeGruttola, A. K., "Current understanding of dysbiosis in disease in human and animal models" 22 : 1137-1150, 2016
75 Venigalla, M., "Curcumin and Apigenin - novel and promising therapeutics against chronic neuroinflammation in Alzheimer's disease" 10 : 1181-1185, 2015
76 Krikorian, R., "Concord grape juice supplementation improves memory function in older adults with mild cognitive impairment" 103 : 730-734, 2010
77 Calani, L., "Colonic metabolism of polyphenols from coffee, green tea, and hazelnut skins" 46 : 95-99, 2012
78 Pase, M. P., "Cocoa polyphenols enhance positive mood states but not cognitive performance: a randomized, placebo-controlled trial" 27 : 451-458, 2013
79 Brown, W. R., "Cerebral microvascular pathology in ageing and neurodegeneration" 37 : 56-74, 2011
80 Sorond, F. A., "Cerebral blood flow response to flavanol-rich cocoa in healthy elderly humans" 4 : 433-440, 2008
81 Marín, L., "Bioavailability of dietary polyphenols and gut microbiota metabolism: antimicrobial properties" 2015 : 2015
82 Manach, C., "Bioavailability and bioefficacy of polyphenols in humans" 81 : 230S-242S, 2005
83 Fraga, C. G., "Basic biochemical mechanisms behind the health benefits of polyphenols" 31 : 435-445, 2010
84 Levites, Y., "Attenuation of 6-hydroxydopamine (6-OHDA)-induced nuclear factor-kappaB (NF-kappaB) activation and cell death by tea extracts in neuronal cultures" 63 : 21-29, 2002
85 Messaoudi, M., "Antidepressant-like effects of a cocoa olyphenolic extract in Wistar-Unilever rats" 11 : 269-276, 2008
86 Xu, Y., "Antidepressant-like effect of trans-resveratrol: involvement of serotonin and noradrenaline system" 20 : 405-413, 2010
87 Krga, I., "Anthocyanins and their gut metabolites reduce the adhesion of monocyte to TNFα-activated endothelial cells at physiologically relevant concentrations" 599 : 51-59, 2016
88 Poulose, S. M., "Anthocyanin-rich açai (Euterpe oleracea Mart.) fruit pulp fractions attenuate inflammatory stress signaling in mouse brain BV-2 microglial cells" 60 : 1084-1093, 2012
89 Turnbaugh, P. J., "An obesity-associated gut microbiome with increased capacity for energy harvest" 444 : 1027-1031, 2006
90 Ghanim, H., "An antiinflammatory and reactive oxygen species suppressive effects of an extract of polygonum cuspidatum containing resveratrol" 95 : E1-E8, 2010
91 Vauzour, D., "Activation of pro-survival Akt and ERK1/2 signalling pathways underlie the anti-apoptotic effects of flavanones in cortical neurons" 103 : 1355-1367, 2007
92 Dueñas, M., "A survey of modulation of gut microbiota by dietary polyphenols" 2015 : 2015
93 Zoetendal, E. G., "A microbial world within us" 59 : 1639-1650, 2006
94 The Human Microbiome Project Consortium, "A framework for human microbiome research" 486 : 215-221, 2012
Minimac3와 Beagle 프로그램을 이용한 한우 770K chip 데이터에서 차세대 염기서열분석 데이터로의 결측치 대치의 정확도 분석
핵산합성 억제제인 decitabine과 NF-κB 활성 저해제인 PDTC의 병용 처리에 의한 인체 위암세포사멸 효과 증진
효모염색체내에 다양한 유전자발현 cassette의 반복적 integration을 위한 system 구축
학술지 이력
연월일 | 이력구분 | 이력상세 | 등재구분 |
---|---|---|---|
2027 | 평가예정 | 재인증평가 신청대상 (재인증) | |
2021-01-01 | 평가 | 등재학술지 유지 (재인증) | ![]() |
2018-01-01 | 평가 | 등재학술지 유지 (등재유지) | ![]() |
2015-01-01 | 평가 | 등재학술지 유지 (등재유지) | ![]() |
2011-08-03 | 학술지명변경 | 외국어명 : Korean Journal of Life Science -> Journal of Life Science | ![]() |
2011-01-01 | 평가 | 등재학술지 유지 (등재유지) | ![]() |
2009-01-01 | 평가 | 등재학술지 유지 (등재유지) | ![]() |
2007-01-01 | 평가 | 등재학술지 유지 (등재유지) | ![]() |
2004-01-01 | 평가 | 등재학술지 선정 (등재후보2차) | ![]() |
2003-01-01 | 평가 | 등재후보 1차 PASS (등재후보1차) | ![]() |
2001-07-01 | 평가 | 등재후보학술지 선정 (신규평가) | ![]() |
학술지 인용정보
기준연도 | WOS-KCI 통합IF(2년) | KCIF(2년) | KCIF(3년) |
---|---|---|---|
2016 | 0.37 | 0.37 | 0.42 |
KCIF(4년) | KCIF(5년) | 중심성지수(3년) | 즉시성지수 |
0.43 | 0.43 | 0.774 | 0.09 |