Two new naphthalenic lactone glycosides from Cassia obtusifolia L. seeds

다국어 초록 (Multilingual Abstract)

Two new naphthalenic lactone glycosides, (3S)-9,10-dihydroxy-7-methoxy-3-methyl-1-oxo-3,4-dihydro-1H-benzo[g]isochromene-3-carboxylic acid 9-O-b-D-glucopyranoside(1) and (3R)-cassialactone 9-O-b-D-glucopyranoside(2) were isolated from seeds of Cassiaobtusifolia Linn., along with five known compounds: (3R)-cassialactone 9-O-b-D-gentiobioside (3), emodin 1-O-bgentiobioside(4), 1-hydroxyl-2-acetyl-3,8-dimethoxynaphthalene6-O-b-D-apiofuranosyl-(1 ? 2)-b-D-glucopyranoside(5), rubrofusarin 6-O-b-D-gentiobioside (6),rubrofusarin 6-O-b-D-triglucoside (7). Structures of 1 and 2were elucidated by NMR and HR-ESI-MS spectroscopicanalysis. Their stereochemistry was determined by CDexperiment. All compounds were tested for their ability toinhibit the formation of advanced glycation end-productsin vitro. Compounds 1, 2, 3, 5, and 6 showed significantin vitro inhibitory activities (IC50 values of 11.63, 23.40,7.32, 89.03, and 38.89 lM, respectively).

참고문헌 (Reference)

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