Lifespan-extending property of 6-shogaol from Zingiber officinale Roscoe in Caenorhabditis elegans

다국어 초록 (Multilingual Abstract)

Aging is a key risk factor for many diseases,understanding the mechanism of which is becoming moreimportant for drug development given the fast-growingaging population. In the course of our continued efforts todiscover anti-aging natural products, the active constituent6-shogaol was isolated from Zingiber officinale Roscoe.
The chemical structure of 6-shogaol was identified bycomparison of its NMR data with literature values. Thelifespan-extending effect of 6-shogaol was observed in adose-dependent manner in Caenorhabditis elegans that hasbeen widely used as a model organism for human agingstudies. Mechanism of such action was investigated usingC. elegans models, suggesting that 6-shogaol is capable ofincreasing stress tolerances via enzyme induction. Theproposed mechanism was further supported by observationof the increase in SOD and HSP expressions upon treatmentwith 6-shogaol in transgenic strains of C. eleganswhich contain GFP-based reporters. In addition, themechanism was elaborated by confirming that the effectobserved for 6-shogaol is independent from other agingrelatedfactors that are known to affect the aging process ofC. elegans.

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