Effect of Rufinamide on the kainic acid-induced excitotoxic neuronal death in the mouse hippocampus

다국어 초록 (Multilingual Abstract)

Rufinamide (RUF) is a structurally unique antiepilepticdrug, used in the treatment of seizure disorderssuch as Lennox-Gastaut syndrome. In the present study, weinvestigated whether RUF protected against excitotoxicneuronal damage in the mouse hippocampal CA3 regionafter intraperitoneal kainic acid (KA) injection. Treatmentwith 25, 50 and 100 mg/kg RUF significantly decreased theKA-induced neuronal death in the hippocampal CA3region in a dose-dependent manner. In addition, 100 mg/kgRUF treatment reduced the KA-induced oxidative stressrelatedincrease of MDA level and decrease of total SODactivity in the hippocampus. KA-induced increases of proinflammatorycytokines, TNF-a and IL-1b, levels as wellas KA-induced microglial activation were also suppressedby RUF treatment. These results indicate that RUF displaysa neuroprotective effect against KA-induced excitotoxicneuronal death in the mouse hippocampus through antioxidantand anti-inflammatory activities.

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