Emerging roles of TRPA1 in sensation of oxidative stress and its implications in defense and danger

다국어 초록 (Multilingual Abstract)

Transient receptor potential ankyrin subtype 1(TRPA1) is a well-known ion channel that play a central rolefor pain sensation. In the peripheral sensory nerve terminalsinnervating the body tegument or organs,TRPA1detects and isactivated by diverse harmful environmental and internalstimuli. TheTRPA1activation results in neuronal firing,whichfinally sends a warning signal to our brain. However, sensitizationor sustained activation of TRPA1 often causes plasticchanges both in the neural pathway and in the peripheral tissues,leading to a pathologic state in tissue health and painmediation. Recently, a unique covalent detection mode forreactive biological attacks was uncovered in the sensorymechanisms of TRPA1. Notably, the pool of the newly foundreactive stimulators forTRPA1includes oxidative stress. Here,we overview the nature of this interaction, and try to findbiological meanings of the participation of such a rapid ionotrophiccomponent in disease exacerbations. Acutely, its relativelyrapid response can be understood in terms of efficiencyfor avoiding harmful milieu as quickly as possible, as implicatedin the raison d’etre of the painmechanism. Nonetheless,complex situations in a chronic disease progressmay occur. Aswell, multiple interplays with known molecules on the redoxdefense mechanism are anticipated. At a therapeutic angle,how to control TRPA1 for promoting body’s defensivepotential will be a practical question but remains to beanswered. Future investigations will likely give more detailedinsights to understand the roles and target validity of TRPA1.

참고문헌 (Reference)

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