자하거(紫河車) 약침(藥鍼)이 βA로 유도(誘導)된 Alzheimer`s Disease 병태(病態) 모델에 미치는 영향(影響) = The Effects of Hominis Placenta Herbal-Acupuncture Solution on the Alzheimer`s Disease Model Induced by βA

다국어 초록 (Multilingual Abstract)

Objective: Hominis Placenta is used in many cure, mainly treats a weak, chronic disease, especially senile. This research investigates the effect of the Hominis Placenta Herbal-Acupuncture Solution on Alzheimer`s disease. Method: The effects of the Hominis Placenta Herbal-Acupuncture Solution on (1) IL-1β protein, TNF-α protein, MDA, and CD68/CD11b (2) the behavior (3) the infarction area of the hippocampus, and brain tissue injury in Alzheimer`s diseased mice induced with βA were investigated. Results: 1. For the Hominis Placenta Herbal-Acupuncture Solution group a significant inhibitory effect on the memory deficit was shown for the mice with Alzheimer`s disease induced by βA in the Morris water maze experiment, which measured stop-through latency, and distance movement-through latency. 2. The Hominis Placenta Herbal-Acupuncture Solution group suppressed the over-expression of IL-1β protein, TNF-α protein, MDA, and CD68/CD11b, in the mice with Alzheimer`s disease induced by βA. 3. The Hominis Placenta Herbal-Acupuncture Solution group reduced the infarction area of hippocampus, and controlled the injury of brain tissue in the mice with Alzheimer`s disease induced by βA. 4. The Hominis Placenta Herbal-Acupuncture Solution group reduced the Tau protein, GFAP protein, and presenilin1/2 protein, beta-secretase protein, (immunohistochemistry) of hippocampus in the mice with Alzheimer`s disease induced by βA. Conclusion: These results suggest that the Hominis Placenta Herbal-Acupuncture Solution group may be effective for the prevention and treatment of Alzheimer`s disease. Investigation into the clinical use of the Hominis Placenta Herbal-Acupuncture Solution for Alzheimer`s disease is suggested for future research. Objective: Hominis Placenta is used in many cure, mainly treats a weak, chronic disease, especially senile. This research investigates the effect of the Hominis Placenta Herbal-Acupuncture Solution on Alzheimer`s disease. Method: The effects of the Hominis Placenta Herbal-Acupuncture Solution on (1) IL-1β protein, TNF-α protein, MDA, and CD68/CD11b (2) the behavior (3) the infarction area of the hippocampus, and brain tissue injury in Alzheimer`s diseased mice induced with βA were investigated. Results: 1. For the Hominis Placenta Herbal-Acupuncture Solution group a significant inhibitory effect on the memory deficit was shown for the mice with Alzheimer`s disease induced by βA in the Morris water maze experiment, which measured stop-through latency, and distance movement-through latency. 2. The Hominis Placenta Herbal-Acupuncture Solution group suppressed the over-expression of IL-1β protein, TNF-α protein, MDA, and CD68/CD11b, in the mice with Alzheimer`s disease induced by βA. 3. The Hominis Placenta Herbal-Acupuncture Solution group reduced the infarction area of hippocampus, and controlled the injury of brain tissue in the mice with Alzheimer`s disease induced by βA. 4. The Hominis Placenta Herbal-Acupuncture Solution group reduced the Tau protein, GFAP protein, and presenilin1/2 protein, beta-secretase protein, (immunohistochemistry) of hippocampus in the mice with Alzheimer`s disease induced by βA. Conclusion: These results suggest that the Hominis Placenta Herbal-Acupuncture Solution group may be effective for the prevention and treatment of Alzheimer`s disease. Investigation into the clinical use of the Hominis Placenta Herbal-Acupuncture Solution for Alzheimer`s disease is suggested for future research.