디프테리아와 파상풍에 대한 연령별 면역혈청학적 연구 = Immunoassay of Diphtheria and Tetanus according to Ages

다국어 초록 (Multilingual Abstract)

Background: The objective of this study was to evaluate protective immunity against diphtheria and tetanus in the Korean population.
Materials and Methods: Healthy subjects were enrolled at four university hospitals in Korea. Subjects were assigned to seven age groups (every 10 years). Enzyme linked immunosorbent assay (ELISA) kits were used for measurement of diphtheria or tetanus anti-toxoid antibodies in sera, and geometric mean concentrations (GMC)of antibodies were determined. Subjects with antibody titers <0.1 IU/mL would require a booster vaccination.
Results: A total of 1,605 subjects participated in this study. In analysis of antibody against diphtheria, subjects in the age group <11 yr showed the highest GMC (1.31IU/mL) while the lowest GMC was observed in subjects in the 31-40 yr age group (0.17IU/mL). With regard to tetanus, subjects in the age group <11 yr also showed the highest GMC (1.81 IU/mL). Among subjects ≥11 yr (600 subjects), 363 (60.5%) would require a diphtheria booster, and 422 (70.4%) would require a tetanus booster.
Conclusions: GMC of antibodies against diphtheria and tetanus of adolescents and adults were relatively low, while those of children in Korea were satisfactory.
Approximately two-thirds of Korean adolescent and adult subjects in this study would require a booster vaccination in order to maintain long-term protective immunity against diphtheria and tetanus.

참고문헌 (Reference)

1 Vetter RT., "Vaccination update. Diphtheria, tetanus, pertussis, mumps, rubella, measles" 98 : 133--145, 1995

2 Khuri-Bulos N., "The changing epidemiology of diphtheria in Jordan" 66 : 65-68, 1988

3 Wassilak SGF., "Tetanus toxoid, In Vaccines. 5th ed" WB Saunders Co. 805-840, 2008

4 Prevots R., "Tetanus surveillance--United States, 1989-1990" 41 : 1-9, 1992

5 Sesardic D., "Testing for neutralising potential of serum antibodies to tetanus and diphtheria toxin" 340 : 737-738, 1992

6 Stark K., "Seroprevalence and determinants of diphtheria, tetanus and poliomyelitis antibodies among adults in Berlin, Germany" 17 : 844-850, 1999

7 Christenson B., "Serological immunity to diphtheria in Sweden in 1978 and 1984" 18 : 227-233, 1986

8 Christenson B., "Serological immunity to diphtheria in Sweden in 1978 and 1984" 18 : 227-233, 1986

9 Lee BK., "Serological immunity to diphtheria among Korean population" 30 : 278-283, 1998

10 Korea Centers for Disease Control and Prevention (KCDC), "Reported tetanus in Korea"

11 Ramsay ME., "Persistence of antibody after accelerated immunisation with diphtheria/tetanus/pertussis vaccine" 302 : 1489-1491, 1991

12 IPSEN J Jr., "Immunization of adults against diphtheria and tetanus" 251 : 459-466, 1954

13 Galazka AM., "Immunization against diphtheria with special emphasis on immunization of adults" 14 : 845-857, 1996

14 Cellesi C., "Immunity to diphtheria in a sample of adult population from central Italy" 7 : 417-420, 1989

15 Anonymous., "Expanded programme on immunization. Outbreak of diphtheria, update" 68 : 134-140, 1993

16 The Korean Pediatric Society, "Diphtheria, pertussis, tetanus vaccines, In Immunization guideline. 6th ed" The Korean Pediatric Society 75-90, 2008

17 Vitek CR., "Diphtheria toxoid, In Vaccines. 5th ed" WB Saunders Co 139-156, 2008

18 Maple PA., "Diphtheria immunity in UK blood donors" 345 : 963-965, 1995

19 Galazka A., "Diphtheria : incidence trends and age-wise changes of immunity" 20 : 355-356, 1988

20 Hardy IR., "Current situation and control strategies for resurgence of diphtheria in newly independent states of the former Soviet Union" 347 : 1739-1744, 1996

21 Kang JH., "Age related serosurvey of immunity to tetanus in Korean populations" 33 : 104-111, 2001

22 Kang JH., "Age related seroepidemiological study of diphtheria among Koreans" 32 : 1-7, 2000

23 Gergen PJ., "A population-based serologic survey of immunity to tetanus in the United States" 332 : 761-766, 1995

24 Gergen PJ., "A population-based serologic survey of immunity to tetanus in the United States" 332 : 761-766, 1995