The altered vascular reactivity in offspring from pregnant mice model of preeclampsia = The altered vascular reactivity in offspring from pregnant mice model of preeclampsia

국문 초록 (Abstract)

목적: The aim of this was to evaluate the effect of maternal preeclampsia on vascular reactivity of offspring in a pregnant mouse model of preelampsia. 방법: At day 8 of gestation pregnant CD-1 mice were randomly allocated to injection using the tail vein of the lentivirus carring sFlt-1 (109 plaque- forming units in 100 microliters; sFlt-1 group) or the mock lentivirus (109 plaque-forming units in 100 microliters; mock group used as a control for the virus) or control group. After delivery, nursing dams and offspring were kept together in individual cages. Offspring from each group were sacrificed at 8 weeks of age, and abdominal aorta was harvested for the study of vascular reactivity. 결과: The vasorelaxant responses to acetylcholine (endothelium-dependent relaxant) were decreased in offspring from sFlt-1 group compared with offspring from control and mock groups. However, there was no difference in vasorelaxant responses to sodium nitroprusside (the endothelium- independent relaxant) between four groups. 결론: Maternal preeclampsia has detrimental effects on vascular reactivity in offspring. Our findings show hypertension of fetal programming in offspring born to preeclamptic mothers.