1 심민교, "향약집성방" 영림사 1810-, 1989
2 육창수, "한약재 관능검사지침(II)" 식품의약품안전청 93-, 2008
3 대한 피부과학회 교과서 편찬위원회, "피부과학(제5 판)" 여문각 136-142, 2008
4 김각균, "최신면역학입문" 이퍼블릭 205-221, 2009
5 안영희, "지치(Lithospermum erythrorhizon) 개체군 자생지의 생태학적 특성" 한국생약학회 40 (40): 289-297, 2009
6 김정민, "자초추출물의 식이공급이 아토피 동물모델 인 NC/Nga mice에게 식이공급하여 세라마이드 함량 및 천연 보습인자의 함량에 미치는 영향" 경희대학교 동서의 학대학원 2006
7 민영기, "자초의 효능에 관한 실험적 연구" 경희대학교 대학원 1993
8 김시혜, "자초가 아토피 피부염에 미치는 영향" 경희대학교 대학원 2004
9 김수용, "자초가 비만세포의 알레르기 염증 반응에 미치는 영향" 경희대학교 대학원 2006
10 박욱연, "자초 추출물의 항균특성" 21 : 97-100, 1992
11 서부일, "임상 한방본초학" 영림사 240-241, 2004
12 약품식품학연구회, "약품식물학각론" 한국학습 교재사 332-, 1982
13 최진규, "약이 되는 우리풀 꽃 나무(1)" 한문화 48-, 2006
14 김진숙, "야생 및 재배 지치뿌리의 Shikonin 화합물 확인" 한국식품영양과학회 35 (35): 177-181, 2006
15 김정희, "아토피피부염의 최신지견" 대한 소아알레르기 호흡기학회 14 (14): 12-23, 2004
16 안성구, "아토피 피부염 진단과 치료" 군자출판사 21-112, 2007
17 김영란, "아토피 동물모델 NC/Nga mice에서 자초 및 보라지 추출물의 식이공급이 소양증,IgE 및 표피 세 라마이드 함량에 미치는 효과 비교" 경희대학교 동서의학 대학원 2007
18 전을, "소아약증직결원문대역" 여강출판사 241-242, 2002
19 김영선, "소아 아토피피부염 환부에서의 이차 세균 감염 빈도와 항생제 감수성에 대한 연구" 대한 소아알레르기 호흡기학회 16 (16): 26-37, 2006
20 김선형, "상엽 우방자 자초가 항알러지 염증반응에 미치는 영향" 경희대학교 대학원 2005
21 권미화, "紫草가 항알러지 염증반응에 미치는 영향" 대한한의학회 26 (26): 110-123, 2005
22 Williams, H., "Worldwide vari ations in the prevalence of symptoms of atopic eczema in the international study of asthma and allergies in childhood" 103 : 125-138, 1999
23 송선영, "UVB에 손상된 생쥐의 피부에 미치는 자초 추출물의 효과" 조선대학교 대학원 2008
24 Fukui, H., "Two phenolic acids from Lithospermm erythrorhizon cell suspension cultures" 23 : 2398-2399, 1984
25 김주영, "The effects of gromwell (Lithospermm erythrorhizon Sieb. et Zucc.) for skin moisturizing and treatment of atopic dermatitis" 경희대학교 동서의학대학원 2006
26 Miamima, R, "The coloring matter of Lithospermum erythrorhizon" 1 : 43-65, 1922
27 Kuroda,C, "The coloring matter in Lithospermum erythrorhizone" 39 : 1051-1115, 1918
28 Papageorgiou, V. P, "The chemistry and biology of alkannin,shikonin,and related naphthazarin natural products" 39 : 270-300, 1999
29 Wang, W. J., "The antiinflammatory activity of shikonin and its inhibitory effect on leukotriene B4 biosynthesis" 29 : 161-165, 1994
30 Christian, V., "The NC/Nga mouse: a model for atopic dermatitis" 6 : 209-210, 2000
31 Kyu Yeon Han, "Suppressive effects of Lithospermum erythrorhizon extracts onlipopolysaccharide-induced activation of AP-1 and NF-κB viamitogen-activated protein kinase pathways in mousemacrophage cells" 한국생화학분자생물학회 41 (41): 328-333, 2008
32 Hisamichi, S, "Studies on the shikon I.Structures of new minor pigments and isolation of two isomers of shikonin derivatives from Lithospermum erythrorhizon Sieb.et Zucc" 36 : 154-159, 1982
33 Yoshizaki, F., "Studies on shikon.III.New furylhydroquinone derivatives,shikonofurans A,B,C,D and E,from Lithospermum erythrorhizon Sieb.et Zucc" 30 : 4407-4411, 1982
34 Staniforth, V., "Shikonins,phytocompounds from Lithospermm erythrorhizon,inhibit the transcriptional activation of human tumor necrosis factor alpha promoter in vivo" 279 : 5877-5885, 2004
35 Nam, K. N., "Shikonins attenuate microglial inflammatory responses by inhibition of ERK,Akt,and NF-κB:neuroprotective implications" 55 : 819-825, 2008
36 Zhang, Y., "Shikonin,an ingredient of Lithospermm erythrorhizon,down-regulates the expression of steroid sulfatase genes in breast cancer cells" 284 : 47-54, 2009
37 Yoon, Y., "Shikonin,an ingredient of Lithospermm erythrorhizon induced apoptosis in HL60 human premyelocytic leukemia cell line" 65 : 532-535, 1999
38 Niwano, Y., "Shikonin,an active principle of the medicinal plant Lithospermm erythrorhizon,is a potent scavenger of peroxyradicals in cigarette smoke" 18 : 201-214, 2007
39 Chen, X., "Shikonin,a component of antiinflammatory Chinese herbal medicine,selectively blocks chemokine binding to CC chemokine receptor-1" 1 : 229-236, 2001
40 Chen, X., "Shikonin,a component of Chinese herbal medicine,inhibits chemokine receptor function and suppresses human immunodeficiency virus type 1" 47 : 2810-2816, 2003
41 Yamamoto, H., "Regulation of lithospermic Acid B and shikonin production in Lithospermm erythrorhizon cell suspension cultures" 50 : 1086-1090, 2002
42 Papageorgioua, V. P, "Recent advances in chemistry,biology and biotechnology of alkannins and shikonins" 10 : 2123-2142, 2006
43 Ishida, T, "Protection of human keratinocytes from UVB-induced inflammation using root extract of Lithospermm erythrorhizon" 30 : 928-934, 2007
44 Cho, M. H., "Propionylshikonin from the roots of Lithospermum erythrorhizon cultivated in Korea" 47 : 4117-4120, 1999
45 Assimopoulou, A. N., "Preparative isolation and purification of alkannin/shikonin derivatives from natural products by high-speed counter-current chromatography" 23 : 182-198, 2009
46 Cho, M. H., "Physical stability of shikonin derivatives from the roots of Lithospermm erythrorhizon cultivated in Korea" 47 : 4117-4120, 1999
47 Hayashi,M, "Pharmacological studies of shikon and tooki. (2) Pharmacological effects of the pigment components, shikonin and acetylshikonin" 73 : 193-203, 1977
48 Hayashi,M, "Pharmaceutical studies on crude plant drugs,shikonin and tooki" 73 : 177-191, 1977
49 Kim, J.-.M., "Oral supplementation of Lithospermm erythrorhizon prevents the development of atopic dermatitis with reducing ceramide degradation in the epidermis of NC/ Nga mice" 23 : 1250-1256, 2009
50 Tanno, O., "Nicotinamide increases biosynthesis of ceramides as well as other stratum corneum lipids to improve the epidermal permeability barrier" 143 : 524-531, 2000
51 Morimoto, I, "New naphthoquinone derivative from Lithospermm erythrorhizon" 7 : 4737-4739, 1965
52 Thuong, P. T., "Lithospermic acid derivatives from Lithospermm erythrorhizon increased expression of serine palmitoyltransferase in human HaCaT cells" 19 : 1815-1817, 2009
53 Kim, E. K., "Lithospermi radix extract inhibits histamine release and production of inflammatory cytokine in mast cells" 71 : 2886-2892, 2007
54 Hong,S.J, "Korean ISAAC Study Group of Korean Association of Allergy and Respiratory Diseases: Report of Korean ISAAC epidemiologic study for asthma and allergic diseases in children" 17 (17): S55-S66, 2007
55 Chiu, S. C, "Inhibition of tumor necrosis factor-alpha through selective blockade of Pre-mRNA splicing by shikonin" 71 : 1640-1645, 2007
56 Ko, F. N., "Inhibition of platelet activation by shikonin derivatives isolated from Arnebia euchroma" 1268 : 329-334, 1995
57 Su, P.-F., "Immunomodulatory effects of phytocompounds characterized by in vivo transgenic human GM-CSF promoter activity in skin tissues" 15 : 813-822, 2008
58 Curtin,M.E, "Harvesting profitable products from plant tissue culture" 1 : 649-657, 1983
59 Fukui, H., "Formation of stereoisomeric mixtures of naphthoquinone derivatives in Echium lycopsis callus cultures" 22 : 453-456, 1983
60 Majlathova,L, "Feeding trial with alkannin on mice" 15 : 505-508, 1971
61 Dae Keun Kim, "Farnesyl Protein Transferase Inhibitory Componentsof Lithospermum erythrorhizon" 한국생약학회 13 (13): 328-331, 2007
62 Lin, L, "Enhancement of shikonin production in single-and two-phase suspension cultures of Lithospermm erythrorhizon cells using low-energy ultrasound" 78 : 81-88, 2002
63 Takwale, A., "Efficacy and tolerability of borage oil in adults and children with atopic eczema:randomised,double blind,placebo controlled,parallel group trial" 327 : 1385-1387, 2003
64 박대원, "Effects of Lithospermi Radix on anti-CD40- and recombinant interleukin-4- induced cytokine production in murine B-cells" 대한본초학회 18 (18): 10-81, 2003
65 Rawlings, A. V., "Effect of lactic acid isomers on keratinocyte ceramide synthesis,stratum corneum lipid levels and stratum corneum barrier function" 288 : 383-390, 1996
66 Dai, B., "Determination of shikonin content in Arnebia euchroma extracts from four kinds of solvent systems and experimental observation on its acute toxicity" 12 : 168-169, 2005
67 Papageorgiou, V. P., "Determination of naturally occurring hydroxynaphthoquinone polymers by size-exclusion chromatography" 55 : 423-430, 2002
68 Hanada, K., "D-Serine inhibits serine palmitoyltransferase,the enzyme catalyzing the initial step of sphingolipid biosynthesis" 474 : 63-65, 2000
69 Brockmann,H, "Constitution of alkannin,shikonin and alkannan" 521 : 1-47, 1935
70 Kyogoku, K., "Constituents of shikon.II.Comparison of contents,constituents,and antibacterial effect of fat soluble fraction between nanshikon and kosikon" 27 : 24-30, 1973
71 Cui, X.-R., "Comparison of the cytotoxic activities of naturally occurring hydroxyanthraquinones and hydroxynaphthoquinones" 43 : 1206-1215, 2008
72 Kim, J., "Comparative effect of gromwell(Lithospermm erythrorhizon)extract and borage oil on reversing epidermal hyperproliferation in guinea pigs" 70 : 2086-2095, 2006
73 Guo, X. P., "Clinical trial on the effects of shikonin mixture on later stage lung cancer" 11 : 598-590, 1991
74 Chen, X., "Cellular pharmacology studies of shikonin derivatives" 16 : 199-209, 2002
75 Yamamoto, H., "Caffeic acid oligomers in Lithospermum erythrorhizon cell suspension cultures" 53 : 651-657, 2000
76 Cooper,K.D, "Atopic dermatitis:recent trends in pathogenesis and therapy" 102 : 128-137, 1994
77 Kim, S.-H., "Antitumor activity of arylacetylshikonin analogs" 19 : 416-422, 1996
78 Han, J., "Antioxidants from a Chinese medicinal herb.Lithospermm erythrorhizon" 106 : 2-10, 2008
79 Weng, X. C., "Antioxidant properties of components extracted from puccoon(Lithospermm erythrorhizon Sieb.et Zucc.)" 69 : 143-146, 2000
80 Karyagina, T. B., "Antimicrobial activity of shikonin preparations" 35 : 435-436, 2001
81 Lee, J. H., "Anti-inflammatory and barrier protecting effect of Lithospermm erythrorhizon extracts in chronic oxazolone-induced murine atopic dermatitis" 256 : 64-66, 2009
82 Fu, S. L., "Analysis of naphthoquinone pigments in Chinese medicinal ‘zicao’.Arnebia euchroma" 19 : 921-920, 1984
83 Papageorgiou, V. P., "Alkannins and Shikonins:A new class of wound healing agents" 15 : 3248-3267, 2008
84 Arakawa, H, "Absolute configuration of shikonin and alkannin" 947 : 1961
85 Wang, W. J., "A study on absorption, distribution and excretion of [3H]shikonin in mice" 23 : 246-251, 1988