Acute interstitial nephritis caused by drugs is an increasingly recognized form of acute renal failure. Early recognition of the etiologic drug is important, since the renal failure is reversible after discontinuation of the drug and rarely may be irr...
Acute interstitial nephritis caused by drugs is an increasingly recognized form of acute renal failure. Early recognition of the etiologic drug is important, since the renal failure is reversible after discontinuation of the drug and rarely may be irreversible if the drug is not stopped. Various NSAIDs may be cause a deterioration of renal function with broad clinical spectrums such as nephrotic syndrome, acute interstitial nephritis, acute renal failure, acute tubular necrosis, papillary necrosis, acute glomerulitis and vasculitis. Fenoprofen appeared to be more nephrotoxic than other NSAIDs and resulted in multiple renal lesions in the same patient. We experienced a case of fenoprofen-induced acute interstitial nephritis. This patient is a 53 years old female who developed a generalized edema, heavy proteinuria and renal insufficiency after taking fenoprofen for eight months. Renal biopsy revealed 1ymphocyte and plasma cell infiltration with focal fibrosis in the interstitium. We noted rapid recovery of renal function by hemodialysis and drub withdrawl. So we report a case of acute interstitial nephritis caused by fenoprofen with a review of the literature.