전기방사를 이용한 경피 약물 전달 체계용 알지네이트 웹 제조 = Preparation of Electrospun Alginate Webs for Transdermal Drug Delivery Systems

다국어 초록 (Multilingual Abstract)

In this study, alginate was electrospun for transdermal drug delivery systems. The spinnability of alginate was improved by the reduction of intra-molecular hydrogen bonding using glycerol. The prepared alginate solutions were electrospun and coagulated in $CaCl_2$ aqueous solution for improved dimensional stability. To observe release ability, the electrospun alginate web was immersed in phosphate buffered saline (PBS) solution. Although 60% of dextran (drug model) was released from the prepared web within 30 minutes, the remaining drug was released continuously over 3 days. The results indicated that the prepared alginate web could be used as a transdermal drug delivery system.

참고문헌 (Reference)

1 구민경, "전기방사와 가교결합을 통한 알지네이트 나노섬유 제조" 한국섬유공학회 50 (50): 323-327, 2013

2 S. Safi., "Study of Electrospinning of Sodium Alginate, Blended Solutions of Sodium Alginate/poly(vinyl alcohol)and Sodium Alginate/poly(ethylene oxide)" 104 : 3245-3255, 2007

3 Y. J. Lee., "Preparation of Atactic Poly(vinyl alcohol)/sodium Alginate Blend Nanowebsby Electrospinning" 106 : 1337-1342, 2007

4 K. A. Kristiansen., "Periodate Oxidized Alginates : Depolymerization Kinetics" 86 : 1595-1601, 2011

5 C. Gomez., "Oxidation of Sodium Alginate and Characterization of the Oxidized Derivatives" 67 : 296-304, 2007

6 B. -J. Lee., "Oral Controlled Release of MelatoninUsing Polymer-reinforced and Coated Alginate Beads" 144 : 37-46, 1996

7 C. K. Kuo., "Ionically Crosslinked Alginate Hydrogels as Scaffolds for Tissue Engineering : Part 1. Structure, Gelation Rate and Mechanical Properties" 22 : 511-521, 2001

8 J. L. Drury., "Hydrogels for Tissue Engineering : Scaffold Design Variables and Applications" 24 : 4337-4351, 2003

9 P. Sikorski., "Evidence for Egg-Box-Compatible Interactions in Calcium-Alginate Gels from Fiber X-ray Diffraction" 8 : 2098-2103, 2007

10 D. -G. Yu., "Electrospun Nanofiber-based Drug Delivery Systems" 1 : 67-75, 2009

11 J. -W. Lu., "Electrospinning of Sodium Alginate with Poly(ethylene oxide)" 47 : 8026-8031, 2006

12 H. Nie., "Effects of Chain Conformation and Entanglement on the Electro-spinning of Pure Alginate" 9 : 1362-1365, 2008

13 H. Nie., "Effect of Poly(ethylene oxide)with Different Molecular Weights on the Electrospinnability of Sodium Alginate" 50 : 4926-4934, 2009

14 O. Smidsrød., "Effect of Periodate Oxidation Upon the Stiffness of the Alginate Molecule in Solution" 26 : 125-132, 1973

15 G. R. Trout., "Effect of Calcium Carbonateand Sodium Alginate on the Textural Characteristics, Color and Color Stability of Restructured Pork Chops" 55 : 38-42, 1990

16 F. -L. Mi., "Drug Release from Chitosan–alginate Complex Beads Reinforced by a Naturally Occurring Cross-linking Agent" 48 : 61-72, 2002

17 T. Boontheekul., "Controlling Alginate Gel Degradation Utilizing Partial Oxidation and Bimodal Molecular Weight Distribution" 26 : 2455-2465, 2005

18 E. R. Morris., "Chiroptical and Stoichiometric Evidence of a Specific, Primary Dimerisation Process in Alginate Gelation" 66 : 145-154, 1978

19 Q. Ain., "Alginate-based Oral Drug Delivery System for Tuberculosis : Pharmacokinetics and Therapeutic Effects" 51 : 931-938, 2003

20 N. Bhattarai., "Alginate-Based Nanofibrous Scaffolds : Structural, Mechanical, and Biological Properties" 18 : 1463-1467, 2006

21 C. Knill., "Alginate Fibres Modified with Unhydrolysed and Hydrolysed Chitosans for Wound Dressings" 55 : 65-76, 2004

22 A. Badwan., "A Sustained Release Drug Delivery System Using Calcium Alginate Beads" 11 : 239-256, 1985