Resting Coronary Blood Flow Velocity by Transthoracic Coronary Echocardiography is Higher in Patients with Cardiovascular Diseases Compared with the Healthy Adults

다국어 초록 (Multilingual Abstract)

Transthoracic Coronary Echocardiography (TCE), defined as blood velocity detection mainly in the left anterior descending artery (LAD) by noninvasive Doppler echocardiography, has been employed to measure coronary blood flow velocity and coronary flow reserve in research labs and in clinical settings. Most prior studies focused on the coronary flow reserve data, and normal values for resting coronary artery flow velocity have rarely been reported. The purpose of this study was to examine resting coronary blood flow velocity in healthy subjects and patients with cardiovascular disease. We retrospectively collected resting coronary blood flow velocity data by TCE from 69 healthy subjects (42 M, 27 F, 60 ± 8 yrs) and 37 patients (27 M, 10 F, 63 ± 10 yrs) with various cardiovascular diseases (14 peripheral arterial disease, 5 Pre‐TAVR, 8 hypertrophy cardiomyopathy, 10 CABG). The patient group had higher systolic blood pressure (135 ± 18 vs. 120±14 mmHg, P value <0.001), mean blood pressure (94 ± 11 vs. 89 ±10 mmHg, P value <0.05), and Rate‐Pressure Product (RPP, an index of myocardial oxygen demand) (8617 ± 1702 vs. 7249 ± 1453. P value < 0.001). Resting coronary blood flow velocities early (CBV1) and late (CBV2) in diastole were significantly higher in the patient group (CBV1: 27.6±8.6 vs. 19.0 ± 4.9 cm/s, P value < 0.001; CBV2: 17.6 ± 5.5 vs. 13.4 ± 3.2 cm/s, P value <0.001). After controlling for oxygen consumption (CBV/RPP), resting coronary blood flow velocity during the early diastolic period was still significantly higher in patients than in the healthy group (Adjusted CBV1: 3.3 ± 1.4 vs. 2.7 ± 0.8 au, P value < 0.001). There was no significant difference in adjusted coronary blood flow velocity during the late diastolic period (Patient group vs. healthy group, 2.1 ± 0.8 vs.1.9 ± 0.5 au, P value = 0.105). Further studies are needed to explore the clinical implication and importance of higher resting coronary blood flow velocity data by TCE in patients.
Support or Funding Information
Supported by National Institutes of Health Grants P01 HL134609 (Sinoway), and UL1 TR002014 (Sinoway).
This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.