<P>Allyl isothiocyanate (AITC), a metabolite of the glucosinolate sinigrin, protects the liver of rats injured by carbon tetrachloride (CCl<SUB>4</SUB>). This study evaluated whether AITC reduces hepatic fibrosis in rats repetitively...
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https://www.riss.kr/link?id=A107704562
2018
-
SCOPUS,SCIE
학술저널
893-897(5쪽)
0
상세조회0
다운로드다국어 초록 (Multilingual Abstract)
<P>Allyl isothiocyanate (AITC), a metabolite of the glucosinolate sinigrin, protects the liver of rats injured by carbon tetrachloride (CCl<SUB>4</SUB>). This study evaluated whether AITC reduces hepatic fibrosis in rats repetitively...
<P>Allyl isothiocyanate (AITC), a metabolite of the glucosinolate sinigrin, protects the liver of rats injured by carbon tetrachloride (CCl<SUB>4</SUB>). This study evaluated whether AITC reduces hepatic fibrosis in rats repetitively exposed to CCl<SUB>4</SUB>. Serum chemistry showed that AITC (doses of 5 and 50 mg) administered to rats exposed to CCl<SUB>4</SUB> significantly reduced the levels of alanine aminotransferase and aspartate aminotransferase activity that were elevated in CCl<SUB>4</SUB>-intoxicated rats. The connective tissue in AITC-treated rats was significantly reduced based on Sirius staining. In addition, Kupffer cell activation was significantly reduced in the AITC and CCl<SUB>4</SUB> co-treated groups. Collectively, this study suggests that AITC mitigates hepatic fibrosis in rats repetitively exposed to CCl<SUB>4</SUB> with concurrent regulation of Kupffer cell and monocyte activation.</P>
A case of unusual persistent pupillary membrane with total anterior capsular pigmentation