디옥시리보스 1-인산에 의한 멜라닌 생성에 미치는 : 칼륨-염소-공동수송체의 역할 = K+-Cl−-cotransport Mediates the Deoxyribose 1-phosphate-Induced Melanogenesis

다국어 초록 (Multilingual Abstract)

The effect of deoxyribose 1-phosphate (dRP) on melanogenesis was investigated in B16 melanoma cells. dRP increased both reactive oxygen species (ROS) levels and melanin content in a dose-dependent manner in B16 cells. These effects were significantly reduced by apocynin (Apo) and diphenyleneiodonium (DPI), which are inhibitors of the NADPH oxidase (NOX). DIOA, a blocker of the K+-Cl−-cotransports (KCCs), significantly inhibited dRP-induced activation of KCCs and melanogenesis. The NOX inhibitors(Apo and DPI) also significantly blocked dRP-induced activation of KCCs. Collectively, these results suggest that dRP may activate KCCs through NOX-mediated ROS production, and in turn, induce melanogenesis in B16 cells.

목차 (Table of Contents)

• 서론(Introduction) 방법(Methods) 결과및고찰(Results and Discussion) 결론(Conclusion) Conflict of Interest References

참고문헌 (Reference)

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