당뇨병 환자의 동공계 반응 = The Pupillary Response to Light in Diabetic Autonomic Neuropathy

다국어 초록 (Multilingual Abstract)

Abnormalities of the pupil of the eye are well known in long-term diabetes and it is well known that changes in the autonomic nervous system can be reflected in the pupil. To investigate the abnormalities of the pupil in diabetics, the pupillary response to light was examined by pupillometry and persistent regular oscillations of the pupil were measured by slit lamp in 44 healthy and 127 diabetic subjects. The diabetic patients had a smaller initial, minimal, and final pupil size and a smaller response amplitude than the control subjects. The maximal velocities of constriction and re-dilatation were reduced in the diabetic patients. An abnormally prolonged dilatation phase (time of maximum redilation velocity)was observed. pupil cycle time was prolonged in a high proportion of patients with evidence of autonomic neuropathy judged by abnormalities of their cardiovascular reflexes. There was significant correlation between results of cardiovascular and pupillary autonomic function tests. In conclusion, Measurement of the pupillary response in darkness was a simple, noninvasive and reproducible method that may yield information about autonomic nervous involvement in diabetics and may be a useful complement to cardiovascular testing in clinical diagnosis fo autonomic neuropathy.