Bisphosphonates in bone disease : from the laboratory to the patient

목차 (Table of Contents)

• 자료제공 :
• Bone and Mineral Metabolism:
  Bone Physiology:
  Morphology.
  Composition of bone.
  Modeling and remodeling.
  Calcium homeostasis.
  Bone as an organ.
  Assessment of bone turnover.
  Bisphosphonates-Preclinical:
  Background to the pharmacological development:
  Chemistry.
  Actions.
  Physicochemical effects.
  Biological effects.
  Inhibition of bone resorption.
  Inhibition of mineralization.
  Pharmocokinetics:
  Intestinal absorption.
  Distribution.
  Renal clearance.
  Other modes of application.
  Animal toxicology:
  Acute toxicology.
  Nonacute toxicology.
  Bisphosphonates-clinical:
  Introduction.
  Paget's Disease:
  Definition.
  Epidemiology.
  Pathophysiology.
  Clinical manifestations.
  Treatment with drugs other than bisphosphonates.
  Treatment with bisphosphonates.
  Osteolytic tumor-induced bone disease:
  Definition.
  Pathophysiology.
  Clinical manifestations.
  Treatment with drugs other than bisphosphonates.
  Treatment with bisphosphonates.
  Non-tumor induced hypercalcemia:
  Definition.
  Pathophysiology.
  Clinical manifestations.
  Treatment with drugs other than bisphosphonates.
  Treatment with bisphosphonates.
  Osteoporosis:
  Definition.
  Epidemiology.
  Pathophysiology.
  Clinical manifestations.
  Treatment with drugs other than bisphosphonates.
  Treatment with bisphosphonates.
  Heterotopic calcification and ossification:
  Definition.
  Pathophysiology.
  Clinical manifestations.
  Treatment with drugs other than bisphosphonates.
  Treatment with bisphosphonates.
  Other diseases:
  Adverse events:
  Bisphosphonates in general.
  Individual bisphosphonates.
  Contraindications.
  Future prospects.
  Commercially available bisphosphonates:
  Index.